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Anti-NKX2-1 Antibody (6Z966)
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Catalog No. TMAH-00818
Alias TTF-1, TTF1, TITF1, Thyroid-specific enhancer-binding protein, Thyroid transcription factor 1, Thyroid nuclear factor 1, T/EBP, NKX2A, Homeobox protein Nkx-2.1, Homeobox protein NK-2 homolog A
Anti-NKX2-1 Antibody (6Z966) is an antibody targeting NKX2-1. Anti-NKX2-1 Antibody (6Z966) can be used in ELISA,FCM,IHC,WB.
Anti-NKX2-1 Antibody (6Z966)
Anti-NKX2-1 Antibody (6Z966)
😃Good
Catalog No. TMAH-00818Alias TTF-1, TTF1, TITF1, Thyroid-specific enhancer-binding protein, Thyroid transcription factor 1, Thyroid nuclear factor 1, T/EBP, NKX2A, Homeobox protein Nkx-2.1, Homeobox protein NK-2 homolog A
Anti-NKX2-1 Antibody (6Z966) is an antibody targeting NKX2-1. Anti-NKX2-1 Antibody (6Z966) can be used in ELISA,FCM,IHC,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $347 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-NKX2-1 Antibody (6Z966) is an antibody targeting NKX2-1. Anti-NKX2-1 Antibody (6Z966) can be used in ELISA,FCM,IHC,WB. |
| Synonyms | TTF-1, TTF1, TITF1, Thyroid-specific enhancer-binding protein, Thyroid transcription factor 1, Thyroid nuclear factor 1, T/EBP, NKX2A, Homeobox protein Nkx-2.1, Homeobox protein NK-2 homolog A |
| Ig Type | Rabbit IgG |
| Clone | 6Z966 |
| Reactivity | Human |
| Verified Activity | 1. Western Blot -Positive WB detected in: HepG2 whole cell lysate, U251 whole cell lysate, U87 whole cell lysate -All lanes: TTF1 antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 39 kDa -Observed band size: 39 kDa 2. IHC image of TMAH-00818 diluted at 1:100 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. 3. IHC image of TMAH-00818 diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. 4. Overlay histogram showing A549 cells stained with TMAH-00818 (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1µg/1*10^6 cells) for 1 h at 4°C.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4°C. Control antibody (green line) was Rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| Application | |
| Recommended Dose | WB:1:500-1:5000; IHC:1:50-1:200; FCM:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Thyroid and lung. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human TTF1 |
| Antigen Species | Human |
| Gene Name | NKX2-1 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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