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Tryptamine hydrochloride

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Catalog No. T124997Cas No. 343-94-2
Alias 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine HCl

Tryptamine hydrochloride is a monoamine alkaloid, metabolite of tryptophan and CNS active substance, agonist of 5-HT4 receptor, TAAR1 and AHR, with potential for blood-brain barrier permeability.

Tryptamine hydrochloride

Tryptamine hydrochloride

🥰Excellent
Purity: 99.89%
Catalog No. T124997Alias 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine HClCas No. 343-94-2
Tryptamine hydrochloride is a monoamine alkaloid, metabolite of tryptophan and CNS active substance, agonist of 5-HT4 receptor, TAAR1 and AHR, with potential for blood-brain barrier permeability.
Pack SizePriceAvailabilityQuantity
5 g$40In Stock
10 g$58In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:99.89%
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Product Introduction

Bioactivity
Description
Tryptamine hydrochloride is a monoamine alkaloid, metabolite of tryptophan and CNS active substance, agonist of 5-HT4 receptor, TAAR1 and AHR, with potential for blood-brain barrier permeability.
In vitro
In perfused cat skin flaps and gastrocnemius muscles, arterial injection of tryptamine hydrochloride (2 mg/0.5 mL) induced significant histamine release (up to 283 µg per injection), along with vasoconstriction and edema formation. This activity confirms that Tryptamine hydrochloride acts as a histamine-releasing agent in vitro[1].
In vivo
Subcutaneous injection of 2 mg Tryptamine hydrochloride (in 0.5 mL) in rats led to a marked reduction in histamine content at the injection site. Repeated intraperitoneal injections totaling 13 mg over 3 days significantly decreased histamine levels in the skin (by 30-46%) and diaphragm (by 26%), indicating systemic histamine release[1].
Alias3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine HCl
Chemical Properties
Molecular Weight196.68
FormulaC10H13ClN2
Cas No.343-94-2
SmilesCl.NCCC1=CNC=2C=CC=CC21
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 50 mg/mL (254.22 mM)
DMSO: 80 mg/mL (406.75 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM5.0844 mL25.4220 mL50.8440 mL254.2201 mL
5 mM1.0169 mL5.0844 mL10.1688 mL50.8440 mL
10 mM0.5084 mL2.5422 mL5.0844 mL25.4220 mL
20 mM0.2542 mL1.2711 mL2.5422 mL12.7110 mL
50 mM0.1017 mL0.5084 mL1.0169 mL5.0844 mL
100 mM0.0508 mL0.2542 mL0.5084 mL2.5422 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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