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Tryptamine hydrochloride

Name: Tryptamine hydrochloride
Brand: TargetMol
SKU: T124997
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T124997Cas No. 343-94-2

Alias 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine HCl

Tryptamine hydrochloride is a monoamine alkaloid, metabolite of tryptophan and CNS active substance, agonist of 5-HT4 receptor, TAAR1 and AHR, with potential for blood-brain barrier permeability.

Tryptamine hydrochloride

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Purity: 99.89%

Catalog No. T124997Alias 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine HClCas No. 343-94-2

Tryptamine hydrochloride is a monoamine alkaloid, metabolite of tryptophan and CNS active substance, agonist of 5-HT4 receptor, TAAR1 and AHR, with potential for blood-brain barrier permeability.

Pack Size	Price	Availability
5 g	$40	In Stock
10 g	$58	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.89%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tryptamine hydrochloride is a monoamine alkaloid, metabolite of tryptophan and CNS active substance, agonist of 5-HT4 receptor, TAAR1 and AHR, with potential for blood-brain barrier permeability.
In vitro	In perfused cat skin flaps and gastrocnemius muscles, arterial injection of tryptamine hydrochloride (2 mg/0.5 mL) induced significant histamine release (up to 283 µg per injection), along with vasoconstriction and edema formation. This activity confirms that Tryptamine hydrochloride acts as a histamine-releasing agent in vitro[1].
In vivo	Subcutaneous injection of 2 mg Tryptamine hydrochloride (in 0.5 mL) in rats led to a marked reduction in histamine content at the injection site. Repeated intraperitoneal injections totaling 13 mg over 3 days significantly decreased histamine levels in the skin (by 30-46%) and diaphragm (by 26%), indicating systemic histamine release[1].
Alias	3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine HCl

Chemical Properties

Molecular Weight	196.68
Formula	C₁₀H₁₃ClN₂
Cas No.	343-94-2
Smiles	Cl.NCCC1=CNC=2C=CC=CC21

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (254.22 mM)

DMSO: 80 mg/mL (406.75 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0844 mL	25.4220 mL	50.8440 mL	254.2201 mL
5 mM	1.0169 mL	5.0844 mL	10.1688 mL	50.8440 mL
10 mM	0.5084 mL	2.5422 mL	5.0844 mL	25.4220 mL
20 mM	0.2542 mL	1.2711 mL	2.5422 mL	12.7110 mL
50 mM	0.1017 mL	0.5084 mL	1.0169 mL	5.0844 mL
100 mM	0.0508 mL	0.2542 mL	0.5084 mL	2.5422 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc