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Anti-HIF1AN Antibody (1I6)

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Catalog No. TMAB-07031

Anti-HIF1AN Antibody (1I6) is a Mouse antibody targeting HIF1AN. Anti-HIF1AN Antibody (1I6) can be used in WB,ICC/IF.

Anti-HIF1AN Antibody (1I6)

Anti-HIF1AN Antibody (1I6)

😃Good
Catalog No. TMAB-07031
Anti-HIF1AN Antibody (1I6) is a Mouse antibody targeting HIF1AN. Anti-HIF1AN Antibody (1I6) can be used in WB,ICC/IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2217-10 days7-10 days
100 μL$3717-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-HIF1AN Antibody (1I6) is a Mouse antibody targeting HIF1AN. Anti-HIF1AN Antibody (1I6) can be used in WB,ICC/IF.
Ig Type
IgG1, k
Clone
1I6
Reactivity
Human
Application
WB
ICC/IF
Recommended Dose
WB: 1:1000-5000; ICC/IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationNucleus. Cytoplasm. Cytoplasm, perinuclearregion. Note=Mainly cytoplasmic localization, but interaction withNOTCH1 results in nuclear localization and interaction with ABPA3results in perinuclear localization in macrophages.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundHIF1AN (Hypoxia inducible factor 1 alpha inhibitor) is a corepressor that interacts with hypoxia inducible factor 1 (HIF1) alpha and the von Hippel Lindau tumor suppressor protein to mediate repression of HIF1 transcriptional activity.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human HIF1AN
Antigen Species
Human
Gene Name
HIF1AN
Gene ID
55662
Protein Name
Hypoxia-inducible factor 1-alpha inhibitor
Uniprot ID
Q5W147
Function
Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminaltransactivation domain (CAD). Functions as an oxygen sensor and,under normoxic conditions, the hydroxylation prevents interactionof HIF-1 with transcriptional coactivators includingCbp/p300-interacting transactivator. Involved in transcriptionalrepression through interaction with HIF1A, VHL and histonedeacetylases. Hydroxylates specific Asn residues within ankyrinrepeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A andseveral other ARD-containing proteins. Also hydroxylates Asp andHis residues within ARDs of ANK1 and TNKS2, respectively.Negatively regulates NOTCH1 activity, accelerating myogenicdifferentiation. Positively regulates ASB4 activity, promotingvascular differentiation.
Chemical Properties
Molecular WeightTheoretical: 38 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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