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Ochromycinone

Name: Ochromycinone
Brand: TargetMol
SKU: T6995
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6995Cas No. 111540-00-2

Alias STA-21, STA21, STA 21

Ochromycinone (STA 21) is a selective STAT3 inhibitor.

Ochromycinone

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Purity: 99.21%

Catalog No. T6995Alias STA-21, STA21, STA 21Cas No. 111540-00-2

Ochromycinone (STA 21) is a selective STAT3 inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	-	In Stock
5 mg	$139	-	In Stock
10 mg	$239	-	In Stock
25 mg	$493	-	In Stock
50 mg	$868	-	In Stock
100 mg	$1,170	-	In Stock
1 mL x 10 mM (in DMSO)	$153	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.21%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ochromycinone (STA 21) is a selective STAT3 inhibitor.
In vitro	In cells, Ochromycinone inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity. Ochromycinone remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. [1] In RH30 and RD2 cells, Ochromycinone also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways. [2]
In vivo	In IL-1Ra–KO mice, STA-21 (0.5 mg/kg, i.p.) reduces the arthritis score and the incidence of arthritis by decreasing the proportion of Th17 cells and increasing the proportion of Treg cells expressing FoxP3. [3]
Cell Research	Human breast cancer cell lines MDA-MB-231, MDA-MB-435s, MDA-MB-453, MDA-MB-468, and MCF7, human ovarian carcinoma cell line Caov-3, and human skin fibroblasts were cultured in DMEM containing 10% FBS and appropriate antibiotics in a 5% CO2 incubator at 37°C. For testing different compounds, the cells were exposed to the compounds for 48 h at a final concentration of 20 or 30 μM, respectively. Then, the cells were harvested and subjected to flow-cytometry analysis.(Only for Reference)
Synonyms	STA-21, STA21, STA 21

Chemical Properties

Molecular Weight	306.31
Formula	C₁₉H₁₄O₄
Cas No.	111540-00-2
Smiles	CC1CC(=O)c2c(C1)ccc1C(=O)c3c(O)cccc3C(=O)c21
Relative Density.	1.387 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 2 mg/mL (6.53 mM), Sonication is recommended.

DMSO: 20 mg/mL (65.29 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Corn Oil: 1.5 mg/mL (4.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2647 mL	16.3233 mL	32.6467 mL	163.2333 mL
5 mM	0.6529 mL	3.2647 mL	6.5293 mL	32.6467 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.3265 mL	1.6323 mL	3.2647 mL	16.3233 mL
20 mM	0.1632 mL	0.8162 mL	1.6323 mL	8.1617 mL
50 mM	0.0653 mL	0.3265 mL	0.6529 mL	3.2647 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc