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NLRP3 agonist 1

Name: NLRP3 agonist 1
Brand: TargetMol
SKU: T81668
Rating: 4.5 (1 reviews)

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Catalog No. T81668Cas No. 2454019-69-1

NLRP3 agonist 1 is an orally active and highly potent NLRP3 agonist that activates the enzyme Caspase-1, which may promote the maturation of pro-inflammatory cytokines.

NLRP3 agonist 1

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Purity: 99.01%

Catalog No. T81668Cas No. 2454019-69-1

NLRP3 agonist 1 is an orally active and highly potent NLRP3 agonist that activates the enzyme Caspase-1, which may promote the maturation of pro-inflammatory cytokines.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	-	In Stock
50 mg	Inquiry	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.01%

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COA

Product Introduction

Bioactivity

Description

NLRP3 agonist 1 is an orally active and highly potent NLRP3 agonist that activates the enzyme Caspase-1, which may promote the maturation of pro-inflammatory cytokines.

Chemical Properties

Molecular Weight	280.33
Formula	C₁₅H₁₆N₆
Cas No.	2454019-69-1
Smiles	N=1NC=CC1C=2C=CC3=C(N=C(N=C3NC4(C)CC4)N)C2

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (285.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5672 mL	17.8361 mL	35.6722 mL	178.3612 mL
5 mM	0.7134 mL	3.5672 mL	7.1344 mL	35.6722 mL
10 mM	0.3567 mL	1.7836 mL	3.5672 mL	17.8361 mL
20 mM	0.1784 mL	0.8918 mL	1.7836 mL	8.9181 mL
50 mM	0.0713 mL	0.3567 mL	0.7134 mL	3.5672 mL
100 mM	0.0357 mL	0.1784 mL	0.3567 mL	1.7836 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc