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Volanesorsen
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Catalog No. T84751Cas No. 915430-78-3
Alias ISIS-304801, ISIS304801, ISIS 304801
Volanesorsen (ISIS 304801) is a chemically stabilized antisense oligonucleotide that selectively inhibits apolipoprotein CIII messenger RNA, resulting in reduced triglyceride levels and improved insulin sensitivity, Volanesorsen is actively studied as a targeted nucleic acid therapeutic strategy for hypertriglyceridemia, familial chylomicronemia syndrome, and type 2 diabetes.
Volanesorsen
Volanesorsen
Copy Product Info😃Good
Catalog No. T84751Alias ISIS-304801, ISIS304801, ISIS 304801Cas No. 915430-78-3
Volanesorsen (ISIS 304801) is a chemically stabilized antisense oligonucleotide that selectively inhibits apolipoprotein CIII messenger RNA, resulting in reduced triglyceride levels and improved insulin sensitivity, Volanesorsen is actively studied as a targeted nucleic acid therapeutic strategy for hypertriglyceridemia, familial chylomicronemia syndrome, and type 2 diabetes.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $189 | - | In Stock | |
| 5 mg | $493 | - | In Stock | |
| 10 mg | $779 | - | In Stock | |
| 25 mg | $1,160 | - | In Stock | |
| 50 mg | $1,570 | - | In Stock | |
| 100 mg | $2,120 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Chemical Properties
Storage & Solubility Information
| Description | Volanesorsen (ISIS 304801) is a chemically stabilized antisense oligonucleotide that selectively inhibits apolipoprotein CIII messenger RNA, resulting in reduced triglyceride levels and improved insulin sensitivity, Volanesorsen is actively studied as a targeted nucleic acid therapeutic strategy for hypertriglyceridemia, familial chylomicronemia syndrome, and type 2 diabetes. |
| In vivo | In human apo-CIII transgenic mice, Volanesorsen treatment (1.5-50 mg/kg, i.p., weekly) for 2 weeks demonstrated a dose-dependent reduction in hepatic human apo-CIII mRNA, plasma apo-CIII protein, and plasma triglycerides (TG). In primate models, efficacy was also observed. specifically, in Cynomolgus monkeys, subcutaneous administration (4-40 mg/kg, weekly) for 13 weeks reduced liver apoC-III mRNA levels in a dose-responsive manner. Furthermore, in hypertriglyceridemic Rhesus monkeys, treatment with 10 mg/kg (s.c., weekly) for 10 weeks lowered plasma triglyceride levels [1][2] |
| Synonyms | ISIS-304801, ISIS304801, ISIS 304801 |
| Molecular Weight | 7165 |
| Cas No. | 915430-78-3 |
| Sequence | DNA, d(P-thio)([2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-m5C-T-T-G-T-m5C-m5C-A-G-m5C-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rU) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | H2O: 40 mg/mL (5.58 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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