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KIF18A-IN-6

🥰Excellent
Catalog No. T73049Cas No. 2914879-10-8

KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor that suppresses KIF18A microtubule-dependent ATPase activity with an IC50 of 0.016 μM. It reduces HCC15 tumour volume in mouse models and may be employed in KIF18A-associated cancer research.

KIF18A-IN-6

KIF18A-IN-6

🥰Excellent
Purity: 97.59%
Catalog No. T73049Cas No. 2914879-10-8
KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor that suppresses KIF18A microtubule-dependent ATPase activity with an IC50 of 0.016 μM. It reduces HCC15 tumour volume in mouse models and may be employed in KIF18A-associated cancer research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$66-In Stock
5 mg$158-In Stock
10 mg$257-In Stock
25 mg$438-In Stock
50 mg$579-In Stock
100 mg$809-In Stock
1 mL x 10 mM (in DMSO)$197-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.59%
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Product Introduction

Bioactivity
Description
KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor that suppresses KIF18A microtubule-dependent ATPase activity with an IC50 of 0.016 μM. It reduces HCC15 tumour volume in mouse models and may be employed in KIF18A-associated cancer research.
Targets&IC50
KIF18A microtubule-dependent ATPase activity:0.016 μM
In vitro
KIF18A-IN-6 demonstrates inhibitory effects on the viability of JIMT-1, HCC-15, and NIH-OVCAR3 cells, with corresponding IC50 values of 0.0040, 0.0051, and 0.0051 μM, respectively. [1]
In vivo
KIF18A-IN-6 (10-60 mg/kg, once or twice daily for 1 month) administered orally effectively inhibited the growth of HCC15 and OVCAR3 tumors in mice. [1]
Chemical Properties
Molecular Weight559.74
FormulaC28H37N3O5S2
Cas No.2914879-10-8
SmilesO=C(C1=CC=CC(=C1)S(=O)(=O)NC(C)(C)C)N2C3=CC=C(C=C3C4(C2)CCC5(CC4)CC5)NS(=O)(=O)CC
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (178.65 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7865 mL8.9327 mL17.8654 mL89.3272 mL
5 mM0.3573 mL1.7865 mL3.5731 mL17.8654 mL
10 mM0.1787 mL0.8933 mL1.7865 mL8.9327 mL
20 mM0.0893 mL0.4466 mL0.8933 mL4.4664 mL
50 mM0.0357 mL0.1787 mL0.3573 mL1.7865 mL
100 mM0.0179 mL0.0893 mL0.1787 mL0.8933 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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