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KIF18A-IN-6

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Catalog No. T73049Cas No. 2914879-10-8

KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor that suppresses KIF18A microtubule-dependent ATPase activity with an IC50 of 0.016 μM. It reduces HCC15 tumour volume in mouse models and may be employed in KIF18A-associated cancer research.

KIF18A-IN-6

KIF18A-IN-6

😃Good
Purity: 97.59%
Catalog No. T73049Cas No. 2914879-10-8
KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor that suppresses KIF18A microtubule-dependent ATPase activity with an IC50 of 0.016 μM. It reduces HCC15 tumour volume in mouse models and may be employed in KIF18A-associated cancer research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$66-In Stock
5 mg$158-In Stock
10 mg$257-In Stock
25 mg$438-In Stock
50 mg$579-In Stock
100 mg$809-In Stock
1 mL x 10 mM (in DMSO)$197-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:97.59%
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Product Introduction

Bioactivity
Description
KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor that suppresses KIF18A microtubule-dependent ATPase activity with an IC50 of 0.016 μM. It reduces HCC15 tumour volume in mouse models and may be employed in KIF18A-associated cancer research.
Targets&IC50
KIF18A microtubule-dependent ATPase activity:0.016 μM
In vitro
KIF18A-IN-6 demonstrates inhibitory effects on the viability of JIMT-1, HCC-15, and NIH-OVCAR3 cells, with corresponding IC50 values of 0.0040, 0.0051, and 0.0051 μM, respectively. [1]
In vivo
KIF18A-IN-6 (10-60 mg/kg, once or twice daily for 1 month) administered orally effectively inhibited the growth of HCC15 and OVCAR3 tumors in mice. [1]
Chemical Properties
Molecular Weight559.74
FormulaC28H37N3O5S2
Cas No.2914879-10-8
SmilesO=C(C1=CC=CC(=C1)S(=O)(=O)NC(C)(C)C)N2C3=CC=C(C=C3C4(C2)CCC5(CC4)CC5)NS(=O)(=O)CC
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (178.65 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 3.3 mg/mL (5.9 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7865 mL8.9327 mL17.8654 mL89.3272 mL
5 mM0.3573 mL1.7865 mL3.5731 mL17.8654 mL
10 mM0.1787 mL0.8933 mL1.7865 mL8.9327 mL
20 mM0.0893 mL0.4466 mL0.8933 mL4.4664 mL
50 mM0.0357 mL0.1787 mL0.3573 mL1.7865 mL
100 mM0.0179 mL0.0893 mL0.1787 mL0.8933 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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