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Zampilimab
🥰Excellent
Catalog No. T76951Cas No. 2098280-42-1
Zampilimab (UCB-7858) is a humanised monoclonal antibody targeting TGM2, which binds to and inhibits the cross-linking transamidase activity of TG2, and is used to improve renal fibrosis.
Zampilimab
Zampilimab
🥰Excellent
Purity: 95%
Catalog No. T76951Cas No. 2098280-42-1
Zampilimab (UCB-7858) is a humanised monoclonal antibody targeting TGM2, which binds to and inhibits the cross-linking transamidase activity of TG2, and is used to improve renal fibrosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $228 | In Stock | |
| 5 mg | $745 | In Stock | |
| 10 mg | $1,180 | In Stock | |
| 25 mg | $2,220 | In Stock | |
| 50 mg | $3,480 | In Stock |
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Concentration:17.732 mg/mL
Purity:95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Zampilimab (UCB-7858) is a humanised monoclonal antibody targeting TGM2, which binds to and inhibits the cross-linking transamidase activity of TG2, and is used to improve renal fibrosis. |
| In vitro | Methods: A renal tubular interstitial fibrosis model was established by treating primary human RPTEC cells with TGF-β1. Extracellular TG2 activity was measured using a biotin-cadaverine incorporation assay, and the inhibitory effect of Zampilimab was evaluated across four independent experiments. Results: Zampilimab significantly inhibited extracellular TG2 activity and reduced ECM accumulation, with an IC₅₀ of 119 nM, indicating strong anti-fibrotic potential. [1] |
| In vivo | Methods: In a cynomolgus monkey model of chronic kidney disease induced by unilateral ureteral obstruction (UUO), Zampilimab was administered intravenously at doses of 10–50 mg/kg once weekly for 21 days to evaluate its effects on in situ TG2 activity and renal fibrosis. Results: Zampilimab treatment effectively reduced in situ TG2 activity in kidney tissue and alleviated renal fibrosis. |
| Cas No. | 2098280-42-1 |
| Color | Transparent |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: buy Zampilimab | purchase Zampilimab | Zampilimab cost | order Zampilimab | Zampilimab in vivo | Zampilimab in vitro
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