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LCS-1

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Catalog No. T60386Cas No. 41931-13-9
Alias LCS1

LCS-1 is a selective superoxide dismutase 1 (SOD1) inhibitor and pyridazin-3-one derivative that displays trypanocidal activity at high concentrations.LCS-1 inhibits superoxide dismutase 1 inducing ROS-dependent death and degrading PARP and BRCA1 in glioma cells.

LCS-1

LCS-1

😃Good
Purity: 99.28%
Catalog No. T60386Alias LCS1Cas No. 41931-13-9
LCS-1 is a selective superoxide dismutase 1 (SOD1) inhibitor and pyridazin-3-one derivative that displays trypanocidal activity at high concentrations.LCS-1 inhibits superoxide dismutase 1 inducing ROS-dependent death and degrading PARP and BRCA1 in glioma cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$40In StockIn Stock
10 mg$73In StockIn Stock
25 mg$132In StockIn Stock
50 mg$193In StockIn Stock
100 mg$287In StockIn Stock
200 mg$428-In Stock
1 mL x 10 mM (in DMSO)$44In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.28%
Appearance:Solid
Color:White
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
LCS-1 is a selective superoxide dismutase 1 (SOD1) inhibitor and pyridazin-3-one derivative that displays trypanocidal activity at high concentrations.LCS-1 inhibits superoxide dismutase 1 inducing ROS-dependent death and degrading PARP and BRCA1 in glioma cells.
Targets&IC50
normal human bronchial epithelial cells:2.66 μM, ANBL6-WT (bortezomib-sensitive) cells:2.5 μM, SOD1:1.07 μM, ANBL6-BR (bortezomib-resistant) cells:4.6 μM
In vitro
LCS-1 (1-10,000 nM, 24 hours) exhibits selective cytotoxicity in HCT116 cells against cells with the BLM gene and BLM-deficient cells. [1]
LCS-1 exhibited inhibitory effects on adenocarcinoma cell lines (e.g., H23, H2347, HCC827, median IC50 of 0.20 μM), whereas the IC50 for normal human bronchial epithelial cells (NHBE) was 2.66 μM.[2]
In multiple myeloma (MM) cells, LCS-1 (0, 1.25, 2 μM, 4 h) significantly inhibited SOD1 enzyme activity in a concentration-dependent manner, and LCS-1 (0, 1.25, 2.5, 5 μM, 48 h) dose-dependently reduced the survival of several MM cell lines, including MM.1R (dexamethasone-resistant), Dox40 (adriamycin-resistant), and LR5 (melphalan-resistant) cell lines. In ANBL6-WT (bortezomib-sensitive) and ANBL6-BR (bortezomib-resistant) cells, the IC50 of LCS-1 treatment for 48 hours was 2.5 μM and 4.6 μM, respectively.[3]
In vivo
In vivo experiments, LCS-1 (20 mg/kg, intraperitoneal injection every other day for 14 days) significantly inhibited the growth of multiple myeloma and prolonged the survival of MM.1S-carrying mice. [3]
SynonymsLCS1
Chemical Properties
Molecular Weight255.1
FormulaC11H8Cl2N2O
Cas No.41931-13-9
SmilesO=C1C(Cl)=C(Cl)C=NN1C2=CC=CC(=C2)C
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (156.8 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2 mg/mL (7.84 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.9200 mL19.6002 mL39.2003 mL196.0016 mL
5 mM0.7840 mL3.9200 mL7.8401 mL39.2003 mL
10 mM0.3920 mL1.9600 mL3.9200 mL19.6002 mL
20 mM0.1960 mL0.9800 mL1.9600 mL9.8001 mL
50 mM0.0784 mL0.3920 mL0.7840 mL3.9200 mL
100 mM0.0392 mL0.1960 mL0.3920 mL1.9600 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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