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LCS-1

🥰Excellent
Catalog No. T60386Cas No. 41931-13-9
Alias LCS1

LCS-1 is a selective superoxide dismutase 1 (SOD1) inhibitor and pyridazin-3-one derivative that displays trypanocidal activity at high concentrations.LCS-1 inhibits superoxide dismutase 1 inducing ROS-dependent death and degrading PARP and BRCA1 in glioma cells.

LCS-1

LCS-1

🥰Excellent
Purity: 99.28%
Catalog No. T60386Alias LCS1Cas No. 41931-13-9
LCS-1 is a selective superoxide dismutase 1 (SOD1) inhibitor and pyridazin-3-one derivative that displays trypanocidal activity at high concentrations.LCS-1 inhibits superoxide dismutase 1 inducing ROS-dependent death and degrading PARP and BRCA1 in glioma cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$40In StockIn Stock
10 mg$73In StockIn Stock
25 mg$132In StockIn Stock
50 mg$193In StockIn Stock
100 mg$287In StockIn Stock
200 mg$428-In Stock
1 mL x 10 mM (in DMSO)$44In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.28%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
LCS-1 is a selective superoxide dismutase 1 (SOD1) inhibitor and pyridazin-3-one derivative that displays trypanocidal activity at high concentrations.LCS-1 inhibits superoxide dismutase 1 inducing ROS-dependent death and degrading PARP and BRCA1 in glioma cells.
Targets&IC50
SOD1:1.07 μM, ANBL6-WT (bortezomib-sensitive) cells:2.5 μM, ANBL6-BR (bortezomib-resistant) cells:4.6 μM, normal human bronchial epithelial cells:2.66 μM
In vitro
LCS-1 (1-10,000 nM, 24 hours) exhibits selective cytotoxicity in HCT116 cells against cells with the BLM gene and BLM-deficient cells. [1]
LCS-1 exhibited inhibitory effects on adenocarcinoma cell lines (e.g., H23, H2347, HCC827, median IC50 of 0.20 μM), whereas the IC50 for normal human bronchial epithelial cells (NHBE) was 2.66 μM.[2]
In multiple myeloma (MM) cells, LCS-1 (0, 1.25, 2 μM, 4 h) significantly inhibited SOD1 enzyme activity in a concentration-dependent manner, and LCS-1 (0, 1.25, 2.5, 5 μM, 48 h) dose-dependently reduced the survival of several MM cell lines, including MM.1R (dexamethasone-resistant), Dox40 (adriamycin-resistant), and LR5 (melphalan-resistant) cell lines. In ANBL6-WT (bortezomib-sensitive) and ANBL6-BR (bortezomib-resistant) cells, the IC50 of LCS-1 treatment for 48 hours was 2.5 μM and 4.6 μM, respectively.[3]
In vivo
In vivo experiments, LCS-1 (20 mg/kg, intraperitoneal injection every other day for 14 days) significantly inhibited the growth of multiple myeloma and prolonged the survival of MM.1S-carrying mice. [3]
SynonymsLCS1
Chemical Properties
Molecular Weight255.1
FormulaC11H8Cl2N2O
Cas No.41931-13-9
SmilesO=C1C(Cl)=C(Cl)C=NN1C2=CC=CC(=C2)C
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (156.8 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2 mg/mL (7.84 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.9200 mL19.6002 mL39.2003 mL196.0016 mL
5 mM0.7840 mL3.9200 mL7.8401 mL39.2003 mL
10 mM0.3920 mL1.9600 mL3.9200 mL19.6002 mL
20 mM0.1960 mL0.9800 mL1.9600 mL9.8001 mL
50 mM0.0784 mL0.3920 mL0.7840 mL3.9200 mL
100 mM0.0392 mL0.1960 mL0.3920 mL1.9600 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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