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CDK7-IN-6 is a highly effective and specific inhibitor (IC50 ≤100 nM) of cyclin-dependent kinase 7 (CDK7). It showcases remarkable selectivity, with more than a 200-fold preference for CDK7 over CDK1, CDK2, and CDK5. This compound holds significant potential for cancer research purposes.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $970 | Inquiry | Inquiry |
| Description | CDK7-IN-6 is a highly effective and specific inhibitor (IC50 ≤100 nM) of cyclin-dependent kinase 7 (CDK7). It showcases remarkable selectivity, with more than a 200-fold preference for CDK7 over CDK1, CDK2, and CDK5. This compound holds significant potential for cancer research purposes. |
| Targets&IC50 | CDK7:≤100 nM (IC50) |
| In vitro | CDK7-IN-6 effectively suppresses cell viability in various cancer cell lines, including HCT116, H460, MV4-11, A2780, and OVCAR cells, demonstrating potent inhibition (IC50 ≤1 μM)[1]. |
| Synonyms | CDK7-IN-6 |
| Molecular Weight | 524.07 |
| Formula | C26H34ClN9O |
| Cas No. | 2378710-04-2 |
| Smiles | CC(C)c1cnn2c(NCc3c(Cl)cccc3-n3ccc(n3)C(C)(C)O)nc(nc12)N1CCC(N)CC1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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