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MAN1B1 Protein, Human, Recombinant (His)

(Synonyms: Mannosidase α Class 1B Member 1, Mannosidase Alpha Class 1B Member 1, Man9GlcNAc2-Specific-Processing α-Mannosidase, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, MAN1B1, ERMan1, ER α-1, ER Mannosidase 1, ER Alpha-1, Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase, 2-Mannosidase, 2-Alpha-Mannosidase) Copy Product Info

Synonyms: Mannosidase α Class 1B Member 1, Mannosidase Alpha Class 1B Member 1, Man9GlcNAc2-Specific-Processing α-Mannosidase, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, MAN1B1, ERMan1, ER α-1, ER Mannosidase 1, ER Alpha-1, Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase, 2-Mannosidase, 2-Alpha-Mannosidase

Catalog No. TMPJ-01384 Copy Product Info
Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.
MAN1B1 Protein, Human, Recombinant (His)
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Pack SizePriceUSA StockGlobal StockQuantity
5 μg$807-10 days7-10 days
10 μg$1297-10 days7-10 days
20 μg$1987-10 days7-10 days
50 μg$3907-10 days7-10 days
100 μg$6267-10 days7-10 days
200 μg$9877-10 days7-10 days
500 μg$1,9007-10 days7-10 days
1 mg$2,7307-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.
Species
Human
Expression System
HEK293 Cells
TagC-6xHis
Accession NumberQ9UKM7
Amino AcidAsp106-Ala699
ConstructionAsp106-Ala699
Protein Purity
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
FormulationSupplied as a 0.2 μm filtered solution of 50 mM Tris-HCl, 10 mM reduced Glutathione, pH 8.0.
Stability & StorageLyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingProteins are shipped with blue ice.
SynonymsMannosidase α Class 1B Member 1, Mannosidase Alpha Class 1B Member 1, Man9GlcNAc2-Specific-Processing α-Mannosidase, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, MAN1B1, ERMan1, ER α-1, ER Mannosidase 1, ER Alpha-1, Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase, 2-Mannosidase, 2-Alpha-Mannosidase
Research Background
Chemical Properties
Molecular Weight58-80 KDa (reducing condition)
Storage & Solubility Information
StorageStore at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months

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Keywords

Related Tags: MAN1B1 Protein, Human, Recombinant (His) chemical structure | MAN1B1 Protein, Human, Recombinant (His) molecular weight