MAN1B1 Protein, Human, Recombinant (His)

Name: MAN1B1 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPJ-01384
Rating: 4.5 (1 reviews)

(Synonyms: Mannosidase α Class 1B Member 1, Mannosidase Alpha Class 1B Member 1, Man9GlcNAc2-Specific-Processing α-Mannosidase, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, MAN1B1, ERMan1, ER α-1, ER Mannosidase 1, ER Alpha-1, Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase, 2-Mannosidase, 2-Alpha-Mannosidase) Copy Product Info

Synonyms: Mannosidase α Class 1B Member 1, Mannosidase Alpha Class 1B Member 1, Man9GlcNAc2-Specific-Processing α-Mannosidase, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, MAN1B1, ERMan1, ER α-1, ER Mannosidase 1, ER Alpha-1, Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase, 2-Mannosidase, 2-Alpha-Mannosidase

Catalog No. TMPJ-01384 Copy Product Info

Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.

MAN1B1 Protein, Human, Recombinant (His)

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Pack Size	Price	USA Stock	Global Stock
10 µg	$129	7-10 days	7-10 days
20 µg	$198	7-10 days	7-10 days
50 µg	$390	7-10 days	7-10 days
100 µg	$626	7-10 days	7-10 days
200 µg	$987	7-10 days	7-10 days
500 µg	$1,900	7-10 days	7-10 days
1 mg	$2,730	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.
Species	Human
Expression System	HEK293 Cells
Tag	C-6xHis
Accession Number	Q9UKM7
Amino Acid	Asp106-Ala699
Construction	Asp106-Ala699
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCl, 10 mM reduced Glutathione, pH 8.0.
Synonyms	Mannosidase α Class 1B Member 1, Mannosidase Alpha Class 1B Member 1, Man9GlcNAc2-Specific-Processing α-Mannosidase, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, MAN1B1, ERMan1, ER α-1, ER Mannosidase 1, ER Alpha-1, Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase, 2-Mannosidase, 2-Alpha-Mannosidase
Research Background	Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.

Chemical Properties

Molecular Weight

58-80 KDa (reducing condition)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.