Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | 5 days | $ 129.00 | |
50 μg | 5 days | $ 390.00 | |
500 μg | 5 days | $ 1,900.00 | |
1 mg | 5 days | $ 2,730.00 |
Description | Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period. |
Species | Human |
Expression System | Human Cells |
Tag | C-6His |
Accession Number | Q9UKM7 |
Synonyms | ER Alpha-1, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, Mannosidase Alpha Class 1B Member 1, MAN1B1, ER α-1, ER Mannosidase 1, Mannosidase α Class 1B Member 1, Man9GlcNAc2-Specific-Processing α-Mannosidase, ERMan1, 2-Mannosidase, 2-Alpha-Mannosidase, 2-α-Mannosidase |
Amino Acid | Asp106-Ala699 |
Construction | Recombinant Human Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase/MAN1B1 is produced by our Mammalian expression system and the target gene encoding Asp106-Ala699 is expressed with a 6His tag at the C-terminus. |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
Molecular Weight | 58-80 KDa, reducing conditions |
Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 10mM reduced Glutathione, pH 8.0. |
Stability & Storage |
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
Shipping |
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
Research Background | Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period. |
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MAN1B1 Protein, Human, Recombinant (His) ER Alpha-1 ER a-1 Man9GlcNAc2-Specific-Processing Alpha-Mannosidase Endoplasmic Reticulum Mannosyl-Oligosaccharide 1 Mannosidase Alpha Class 1B Member 1 Man9GlcNAc2-Specific-Processing a-Mannosidase MAN1B1 ER α-1 ER Mannosidase 1 2-a-Mannosidase Mannosidase α Class 1B Member 1 Mannosidase a Class 1B Member 1 Man9GlcNAc2-Specific-Processing α-Mannosidase ERMan1 2-Mannosidase 2-Alpha-Mannosidase 2-α-Mannosidase recombinant recombinant-proteins proteins protein