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Synonyms: Mannosidase α Class 1B Member 1, Mannosidase Alpha Class 1B Member 1, Man9GlcNAc2-Specific-Processing α-Mannosidase, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, MAN1B1, ERMan1, ER α-1, ER Mannosidase 1, ER Alpha-1, Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase, 2-Mannosidase, 2-Alpha-Mannosidase


| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $80 | 7-10 days | 7-10 days | |
| 10 μg | $129 | 7-10 days | 7-10 days | |
| 20 μg | $198 | 7-10 days | 7-10 days | |
| 50 μg | $390 | 7-10 days | 7-10 days | |
| 100 μg | $626 | 7-10 days | 7-10 days | |
| 200 μg | $987 | 7-10 days | 7-10 days | |
| 500 μg | $1,900 | 7-10 days | 7-10 days | |
| 1 mg | $2,730 | 7-10 days | 7-10 days |
| Description | Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-6xHis |
| Accession Number | Q9UKM7 |
| Amino Acid | Asp106-Ala699 |
| Construction | Asp106-Ala699 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCl, 10 mM reduced Glutathione, pH 8.0. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Proteins are shipped with blue ice. |
| Synonyms | Mannosidase α Class 1B Member 1, Mannosidase Alpha Class 1B Member 1, Man9GlcNAc2-Specific-Processing α-Mannosidase, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, MAN1B1, ERMan1, ER α-1, ER Mannosidase 1, ER Alpha-1, Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase, 2-Mannosidase, 2-Alpha-Mannosidase |
| Research Background |
| Molecular Weight | 58-80 KDa (reducing condition) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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