Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a state of leptin-resistance, thus a protein-like BMP7 which acts through a leptin-independent pathway could give new therapeutic directions.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | Inquiry | $ 310.00 | |
50 μg | Inquiry | $ 1,165.00 | |
500 μg | Inquiry | $ 5,832.00 |
Description | Recombinant Human Bone morphogenetic protein 7 is produced by our Mammalian expression system and the target gene encoding Ser293-His431 is expressed. |
Species | Human |
Expression System | Human Cells |
Tag | Tag Free |
Accession Number | P18075 |
Synonyms | Eptotermin alfa, OP-1, OP1, Osteogenic protein 1, Bone morphogenetic protein 7, BMP7 |
Amino Acid | Ser293-His431 |
Construction | Recombinant Human Bone morphogenetic protein 7 is produced by our Mammalian expression system and the target gene encoding Ser293-His431 is expressed. |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. |
Molecular Weight | 18-23 KDa, reducing conditions |
Endotoxin | Less than 1 EU/µg as determined by LAL test. |
Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 100mM NaCl, 5% Mannitol,0.05% Tween80, pH7.5. |
Stability & Storage |
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
Shipping |
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
Research Background | Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a state of leptin-resistance, thus a protein-like BMP7 which acts through a leptin-independent pathway could give new therapeutic directions. |
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Please read the User Guide of Recombinant Proteins for more specific information.
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