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IMMH 010 maleate

Catalog No. T83970 CAS 2541982-47-0

Synonyms: YPD-30 maleate

IMMH 010 maleate (YPD-30 maleate) is an orally available programmed cell death ligand 1 inhibitor with potential antitumor activity for the study of neurological disorders and advanced malignant solid tumors.

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IMMH 010 maleate, CAS 2541982-47-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 483.00
10 mg	In stock	$ 692.00
25 mg	In stock	$ 1,080.00
50 mg	In stock	$ 1,490.00
100 mg	In stock	$ 1,970.00

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Biological Description

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Description	IMMH 010 maleate (YPD-30 maleate) is an orally available programmed cell death ligand 1 inhibitor with potential antitumor activity for the study of neurological disorders and advanced malignant solid tumors.
In vitro	IMMH-010 maleate (YPD-30) is an ester prodrug of YPD-29B, which is an effective small-molecule inhibitor targeting hPD-L1 in vitro[1].
In vivo	IMMH-010 maleate (YPD-30; 2.5, 5, and 10 mg/kg; oral administration, twice weekly) significantly delayed tumor progression in mice compared to the vehicle group in a dose-dependent manner. The tumor growth inhibition rates (TGI) were 40.5% (2.5 mg/kg), 60.9% (5 mg/kg), and 67.9% (10 mg/kg), respectively[1].

Synonyms	YPD-30 maleate
Molecular Weight	756.04
Formula	C36H36BrClN2O9
CAS No.	2541982-47-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jiang J,et al. Simultaneous Determination of a Novel PD-L1 Inhibitor, IMMH-010, and Its Active Metabolite, YPD-29B, in Rat Biological Matrices by Polarity-Switching Liquid Chromatography-Tandem Mass Spectrometry: Application to ADME Studies. Front Pharmacol. 2021 Jun 21;12:677120. 2. Lai F,et al. Erratum: Author correction to "YPD-30, a prodrug of YPD-29B, is an oral small-molecule inhibitor targeting PD-L1 for the treatment of human cancer" [Acta Pharmaceutica Sinica B 12 (2022) 2845-2858]. Acta Pharm Sin B. 2023 Jul;13(7):3178-3179.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IMMH 010 maleate 2541982-47-0 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 YPD-30 maleate IMMH010maleate inhibitor inhibit

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