Shopping Cart

Your shopping cart is currently empty

BRM/BRG1 ATP Inhibitor-1

Name: BRM/BRG1 ATP Inhibitor-1
Brand: TargetMol
SKU: T10616
Price: 179 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T10616Cas No. 2270879-17-7

BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s<0.005 μM).

BRM/BRG1 ATP Inhibitor-1

Copy Product Info

🥰Excellent

Purity: 99.84%

Catalog No. T10616Cas No. 2270879-17-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$179	In Stock	In Stock
5 mg	$455	In Stock	In Stock
10 mg	$683	In Stock	In Stock
25 mg	$1,180	In Stock	In Stock
50 mg	$1,730	In Stock	In Stock
100 mg	$2,430	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$490	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.84%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

BRM/BRG1 ATP Inhibitor-1 AI Summary

BRM/BRG1 ATP Inhibitor-1 exhibits multiple bioactivities, including significant inhibition of BRM/BRG1 mutants in human cells, leading to reduced KRT80 gene expression in vivo. It demonstrates potent anti-tumor activity in human cells xenografted in athymic nude mice, effectively inhibiting tumor growth at various dosages. The compound reaches the required unbound plasma concentration within a specific timeframe to mediate gene expression reduction. In luciferase reporter gene assays, BRM/BRG1 ATP Inhibitor-1 shows an EC50 value indicative of its efficacy in inhibiting BRM/BRG1 mutants. Additionally, it possesses noteworthy thermodynamic solubility at a defined pH. The compound also inhibits human cell proliferation, reflected in cell growth suppression, and demonstrates inhibitory effects on BRM/BRG1 mutant-dependent cell proliferation across different cell types, with varied EC50 values. Furthermore, BRM/BRG1 ATP Inhibitor-1 has been found to inhibit recombinant ATPases expressed in insect sf9 cells, with distinct IC50 values, illustrating its broad scope of bioactivity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s<0.005 μM).
Targets&IC50	BRM/BRG1:﹤0.005 µM

Chemical Properties

Molecular Weight	318.27
Formula	C₁₁H₉F₃N₄O₂S
Cas No.	2270879-17-7
Smiles	OCc1cnc(F)cc1NC(=O)Nc1cc(ns1)C(F)F
Relative Density.	1.659 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 145 mg/mL (455.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (15.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1420 mL	15.7099 mL	31.4199 mL	157.0993 mL
5 mM	0.6284 mL	3.1420 mL	6.2840 mL	31.4199 mL
10 mM	0.3142 mL	1.5710 mL	3.1420 mL	15.7099 mL
20 mM	0.1571 mL	0.7855 mL	1.5710 mL	7.8550 mL
50 mM	0.0628 mL	0.3142 mL	0.6284 mL	3.1420 mL
100 mM	0.0314 mL	0.1571 mL	0.3142 mL	1.5710 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc