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WDR5-0103

Name: WDR5-0103
Brand: TargetMol
SKU: T3201
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3201Cas No. 890190-22-4

Alias WD-Repeat Protein 5-0103

WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).

WDR5-0103

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Purity: 99.61%

Catalog No. T3201Alias WD-Repeat Protein 5-0103Cas No. 890190-22-4

WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$38	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$131	In Stock	In Stock
50 mg	$232	In Stock	In Stock
100 mg	$343	In Stock	In Stock
200 mg	$489	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.61%

Color:Yellow

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Product Introduction

WDR5-0103 AI Summary

WDR5-0103 exhibits multiple bioactivities across various assays. It shows inhibitory activity by preventing the binding of N-terminal FITC-GSARAEVHLRKS to WDR5 with a binding constant (Kd) of 3000.0 nM as determined by a fluorescence polarization assay. In terms of antiviral properties, WDR5-0103 inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 cells with an inhibition rate of 1.38% at 10 µM after 48 hours, and in VERO-6 cells it shows a 0.44% inhibition rate under the same conditions. Additionally, it partially inhibits SARS-CoV-2 3CL-Pro protease activity by 3.53% at a concentration of 20 µM, detected through a FRET response. Furthermore, WDR5-0103 demonstrates variable inhibition in HDAC6 enzymatic activity assays, with a 5.02% inhibition using a commercial peptide substrate and a negative inhibition of -8.3% with a custom peptide substrate. Overall, the bioactivity of WDR5-0103 may depend on specific assay conditions and substrates employed..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).
Targets&IC50	WDR5:450 nM
Synonyms	WD-Repeat Protein 5-0103

Chemical Properties

Molecular Weight	383.44
Formula	C₂₁H₂₅N₃O₄
Cas No.	890190-22-4
Smiles	COC(=O)c1ccc(N2CCN(C)CC2)c(NC(=O)c2cccc(OC)c2)c1
Relative Density.	1.223 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (156.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6080 mL	13.0398 mL	26.0797 mL	130.3985 mL
5 mM	0.5216 mL	2.6080 mL	5.2159 mL	26.0797 mL
10 mM	0.2608 mL	1.3040 mL	2.6080 mL	13.0398 mL
20 mM	0.1304 mL	0.6520 mL	1.3040 mL	6.5199 mL
50 mM	0.0522 mL	0.2608 mL	0.5216 mL	2.6080 mL
100 mM	0.0261 mL	0.1304 mL	0.2608 mL	1.3040 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc