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Boc-Val-Cit-PAB-PNP

🥰Excellent
Catalog No. T17692Cas No. 870487-10-8

Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Boc-Val-Cit-PAB-PNP

Boc-Val-Cit-PAB-PNP

🥰Excellent
Purity: 97.9%
Catalog No. T17692Cas No. 870487-10-8
Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$31In StockIn Stock
25 mg$47In StockIn Stock
50 mg$65In StockIn Stock
100 mg$95In StockIn Stock
200 mg$138In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:97.9%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
In vitro
ADCs consist of an antibody attached to an ADC cytotoxin through an ADC linker.
Chemical Properties
Molecular Weight644.67
FormulaC30H40N6O10
Cas No.870487-10-8
SmilesCC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(COC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc1
Relative Density.1.291 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mM, Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5512 mL7.7559 mL15.5118 mL77.5591 mL
5 mM0.3102 mL1.5512 mL3.1024 mL15.5118 mL
10 mM0.1551 mL0.7756 mL1.5512 mL7.7559 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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Keywords

InhibitorinhibitCleavableBoc-Val-Cit-PAB-PNPBocValCitPABPNPBoc Val Cit PAB PNPAntibody-drug conjugates linkersADCLinkerADC LinkersADC Linker
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