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Anti-GPR120 Polyclonal Antibody
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Catalog No. TMAB-00789
Alias PGR4, PGR 4, Omega-3 fatty acid receptor 1, O3FAR1, O3FA1, MGC119984, HGNC:19345, GT01, GPR129, GPR120, GPR 129, GPR 120, GPCR GPR120, G protein coupled receptor PGR4, G protein coupled receptor PGR 4, G protein coupled receptor GT01, G protein coupled receptor 129, G protein coupled receptor 120
Anti-GPR120 Polyclonal Antibody is a Rabbit antibody targeting GPR120. Anti-GPR120 Polyclonal Antibody can be used in ELISA,ICC/IF,WB.
Anti-GPR120 Polyclonal Antibody
Anti-GPR120 Polyclonal Antibody
😃Good
Catalog No. TMAB-00789Alias PGR4, PGR 4, Omega-3 fatty acid receptor 1, O3FAR1, O3FA1, MGC119984, HGNC:19345, GT01, GPR129, GPR120, GPR 129, GPR 120, GPCR GPR120, G protein coupled receptor PGR4, G protein coupled receptor PGR 4, G protein coupled receptor GT01, G protein coupled receptor 129, G protein coupled receptor 120
Anti-GPR120 Polyclonal Antibody is a Rabbit antibody targeting GPR120. Anti-GPR120 Polyclonal Antibody can be used in ELISA,ICC/IF,WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $373 | 7-10 days | |
| 200 μL | $527 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-GPR120 Polyclonal Antibody is a Rabbit antibody targeting GPR120. Anti-GPR120 Polyclonal Antibody can be used in ELISA,ICC/IF,WB. |
| Synonyms | PGR4, PGR 4, Omega-3 fatty acid receptor 1, O3FAR1, O3FA1, MGC119984, HGNC:19345, GT01, GPR129, GPR120, GPR 129, GPR 120, GPCR GPR120, G protein coupled receptor PGR4, G protein coupled receptor PGR 4, G protein coupled receptor GT01, G protein coupled receptor 129, G protein coupled receptor 120 |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Dog,Pig,Cow,Rabbit) |
| Application | |
| Recommended Dose | WB: 1:500-2000; ICC/IF: 1:100-500; ELISA: 1:5000-10000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane. Colocalized with ARRB2 following DHA treatment. |
| Tissue Specificity | Abundant expression in the intestinal tract. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | GPR120, a member of the rhodopsin family of G protein-coupled receptors (GPCRs), is a 377 amino acid protein which is expressed in the intestine. GPR120 is a receptor for unsaturated long-chain FFAs (free fatty acids). FFAs act as signaling molecules and are an important energy source. They also employ various physiological responses through their GPCRs. One such response occurs when dietary FFAs stimulate GPR120. This stimulation promotes the secretion of glucagon-like peptide 1 (GLP-1) in vivo and in vitro. GLP-1 belongs to the class of molecules known as the incretins, which are associated with insulin secreted from the pancreas as a result of food intake. GLP-1 also inhibits glucagon and gastric acid secretion and gastric emptying. Consequently, the role of GPR120 in the secretion of GLP-1 is critical in the treatment of diabetes. |
| Immunogen | KLH conjugated synthetic peptide: human G protein coupled receptor 120 |
| Antigen Species | Human |
| Gene Name | FFAR4 |
| Gene ID | |
| Protein Name | Free fatty acid receptor 4 |
| Uniprot ID | |
| Biology Area | Lipid metabolism,GPCR |
| Function | Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects particulary in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediates the taste of fatty acids. |
| Molecular Weight | Theoretical: 42 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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