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Honokiol

Honokiol
Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
Catalog No. T3001Cas No. 35354-74-6
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Purity:99.87%
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Honokiol

Catalog No. T3001Cas No. 35354-74-6

Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
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Pack SizePriceAvailabilityQuantity
50 mg$50In Stock
100 mg$63In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
In vitro
Honokiol inhibits the growth of RKO cell tumors in transplanted mice and effectively counters SVR sarcoma in nude mice. Furthermore, when treating transplanted tumors in mice, Honokiol suppresses the growth of MDA-MD-231 breast cancer cells.
In vivo
Honokiol exhibits direct antiangiogenic activity by blocking the phosphorylation and racemization triggered by VEGF-VEGFR2 interaction. It promotes apoptosis in CLL cells through the activation of caspase 8, which then activates caspase 9 and 3. Honokiol demonstrates pro-apoptotic effects in cell lines of melanoma, sarcoma, myeloma, leukemia, bladder cancer, lung cancer, prostate cancer, oral squamous cell carcinoma, and colon cancer. It effectively induces apoptosis in SVR sarcoma cells and inhibits the survival of CLL cells mediated by interleukin-4, enhancing the cytotoxicity of bendamustine, fludarabine, and cladribine. Honokiol kills myeloma cells in relapsed patients at doses that do not harm PBMCs. Treatment with Honokiol reduces the phosphorylation of MAP, akt, and c-src in SVR cells. Moreover, Honokiol treatment induces the cleavage of caspase 3, 7, 8, 9, and PARP. It also induces apoptosis in colon cancer cells RKO, enhances apoptosis, and suppresses osteoclastogenesis and invasiveness by regulating the NF-κB activation pathway.
Cell Research
Honokiol is dissolved in DMSO. In cytotoxicity assays, 10,000 cells/well are added to 96 wells plates and incubated overnight, thereafter cells are treated with different concentrations of Honokiol dissolved in dimethylsulphoxide (DMSO). Since Honokiol is not soluble in aqueous solvents, for in vitro studies Honokiol is dissolved in DMSO. To study the possible effect of DMSO on cells, solvent (DMSO) control is used at highest concentration of <0.1%. After 72 h treatment, cells are fixed and cell viability is measured by crystal violet staining (0.05%).
AliasNSC 293100
Chemical Properties
Molecular Weight266.33
FormulaC18H18O2
Cas No.35354-74-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 26.6 mg/mL (100 mM)
DMSO: 55 mg/mL (206.51 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.7547 mL18.7737 mL37.5474 mL187.7370 mL
5 mM0.7509 mL3.7547 mL7.5095 mL37.5474 mL
10 mM0.3755 mL1.8774 mL3.7547 mL18.7737 mL
20 mM0.1877 mL0.9387 mL1.8774 mL9.3869 mL
50 mM0.0751 mL0.3755 mL0.7509 mL3.7547 mL
100 mM0.0375 mL0.1877 mL0.3755 mL1.8774 mL

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