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(E/Z)-Rigosertib sodium

Name: (E/Z)-Rigosertib sodium
Brand: TargetMol
SKU: T6070
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6070Cas No. 1225497-78-8

Alias (E/Z) ON-01910 sodium

ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.

(E/Z)-Rigosertib sodium

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Purity: 99.82%

Catalog No. T6070Alias (E/Z) ON-01910 sodiumCas No. 1225497-78-8

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$34	In Stock	In Stock
5 mg	$55	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$193	In Stock	In Stock
50 mg	$363	In Stock	In Stock
100 mg	$622	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$72	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Color:Yellow

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.
Targets&IC50	PDGFR:18 nM(Cell-free assay) , FLK1:42 nM(Cell-free assay) , PLK1:9 nM(Cell-free assay) , BCR-ABL:32 nM(Cell-free assay) , Src:55 nM(Cell-free assay)
In vitro	ON01910, a small molecule inhibitor of Plk1 activity, which induces mitotic arrest of tumor cells characterized by spindle abnormalities leading to their apoptosis.?This compound was not ATP-competitive, but competed for the substrate binding site of the enzyme[1].
In vivo	In vivo, this compound did not exhibit hematotoxicity, liver damage, or neurotoxicity, and was a potent inhibitor of tumor growth in a variety of xenograft nude mouse models.?ON01910 showed strong synergy with several chemotherapeutic agents, often inducing complete regression of tumors[1].
Synonyms	(E/Z) ON-01910 sodium

Chemical Properties

Molecular Weight	473.47
Formula	C₂₁H₂₄NNaO₈S
Cas No.	1225497-78-8
Smiles	[Na+].COc1cc(OC)c(C=CS(=O)(=O)Cc2ccc(OC)c(NCC([O-])=O)c2)c(OC)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 94 mg/mL (198.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1121 mL	10.5603 mL	21.1207 mL	105.6033 mL
5 mM	0.4224 mL	2.1121 mL	4.2241 mL	21.1207 mL
10 mM	0.2112 mL	1.0560 mL	2.1121 mL	10.5603 mL
20 mM	0.1056 mL	0.5280 mL	1.0560 mL	5.2802 mL
50 mM	0.0422 mL	0.2112 mL	0.4224 mL	2.1121 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0560 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc