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I-XW-053

Name: I-XW-053
Brand: TargetMol
SKU: T20000
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20000Cas No. 5496-35-5

I-XW-053 is a micromolar affinity inhibitor of capsid-targeted HIV-1 replication, utilizing a hybrid structure-based method to block the interface between CA N-terminal domains (NTD-NTD interface).

I-XW-053

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Purity: 99.05%

Catalog No. T20000Cas No. 5496-35-5

I-XW-053 is a micromolar affinity inhibitor of capsid-targeted HIV-1 replication, utilizing a hybrid structure-based method to block the interface between CA N-terminal domains (NTD-NTD interface).

Pack Size	Price	Availability	Quantity
500 mg	$29	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.05%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

I-XW-053 is a micromolar affinity inhibitor of capsid-targeted HIV-1 replication, utilizing a hybrid structure-based method to block the interface between CA N-terminal domains (NTD-NTD interface).

Chemical Properties

Molecular Weight	340.37
Formula	C₂₂H₁₆N₂O₂
Cas No.	5496-35-5
Smiles	OC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Relative Density.	1.263g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (146.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9380 mL	14.6899 mL	29.3798 mL	146.8990 mL
5 mM	0.5876 mL	2.9380 mL	5.8760 mL	29.3798 mL
10 mM	0.2938 mL	1.4690 mL	2.9380 mL	14.6899 mL
20 mM	0.1469 mL	0.7345 mL	1.4690 mL	7.3449 mL
50 mM	0.0588 mL	0.2938 mL	0.5876 mL	2.9380 mL
100 mM	0.0294 mL	0.1469 mL	0.2938 mL	1.4690 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc