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CEP-11981 (ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI) targeting TIE2, VEGFR1-3, and FGFR1, exhibiting potential anti-tumor and anti-angiogenic effects.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $4,070 | In Stock | |
50 mg | $6,430 | In Stock | |
100 mg | $9,710 | 10-14 weeks |
Description | CEP-11981 (ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI) targeting TIE2, VEGFR1-3, and FGFR1, exhibiting potential anti-tumor and anti-angiogenic effects. |
In vivo | Calcium channel-modulator-1 (20 mg/kg ; p.o.) causes a 35-37% decrease in systolic blood pressure in spontaneously hypertensive rats. However, iv administration of Calcium channel-modulator-1 to anesthetized spontaneously hypertensive rats causes a decrease in blood pressure.[1] |
Alias | ESK981 ; BOL 303213X, ESK981, BOL 303213X |
Molecular Weight | 477.56 |
Formula | C28H27N7O |
Cas No. | 856691-93-5 |
Smiles | C(C(C)C)N1C=2C(C=3C1=CC=C(NC=4N=CC=CN4)C3)=C5C(=C6C2CCC=7C6=CN(C)N7)C(=O)NC5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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