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CEP-11981

Name: CEP-11981
Brand: TargetMol
SKU: T68539
Price: 4070 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68539Cas No. 856691-93-5

Alias ESK981 ; BOL 303213X, ESK981, BOL 303213X

CEP-11981 (ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI) targeting TIE2, VEGFR1-3, and FGFR1, exhibiting potential anti-tumor and anti-angiogenic effects.

CEP-11981

😃Good

Catalog No. T68539Alias ESK981 ; BOL 303213X, ESK981, BOL 303213XCas No. 856691-93-5

CEP-11981 (ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI) targeting TIE2, VEGFR1-3, and FGFR1, exhibiting potential anti-tumor and anti-angiogenic effects.

Pack Size	Price	Availability
25 mg	$4,070	In Stock
50 mg	$6,430	In Stock
100 mg	$9,710	10-14 weeks

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Product Introduction

Bioactivity

Description	CEP-11981 (ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI) targeting TIE2, VEGFR1-3, and FGFR1, exhibiting potential anti-tumor and anti-angiogenic effects.
In vivo	Calcium channel-modulator-1 (20 mg/kg ; p.o.) causes a 35-37% decrease in systolic blood pressure in spontaneously hypertensive rats. However, iv administration of Calcium channel-modulator-1 to anesthetized spontaneously hypertensive rats causes a decrease in blood pressure.[1]
Alias	ESK981 ; BOL 303213X, ESK981, BOL 303213X

Chemical Properties

Molecular Weight	477.56
Formula	C₂₈H₂₇N₇O
Cas No.	856691-93-5
Smiles	C(C(C)C)N1C=2C(C=3C1=CC=C(NC=4N=CC=CN4)C3)=C5C(=C6C2CCC=7C6=CN(C)N7)C(=O)NC5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ESK981 ; BOL 303213XESK-981ESK 981CEP-11981CEP11981CEP 11981BOL-303213XBOL303213X