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Anti-PAK3 Polyclonal Antibody

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Catalog No. TMAB-09941

Anti-PAK3 Polyclonal Antibody is a Rabbit antibody targeting PAK3. Anti-PAK3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-PAK3 Polyclonal Antibody

Anti-PAK3 Polyclonal Antibody

😃Good
Catalog No. TMAB-09941
Anti-PAK3 Polyclonal Antibody is a Rabbit antibody targeting PAK3. Anti-PAK3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3727-10 days7-10 days
200 μL$5287-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-PAK3 Polyclonal Antibody is a Rabbit antibody targeting PAK3. Anti-PAK3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Human,Mouse (predicted:Chicken,Dog,Pig,Horse,Rabbit)
Application
IHC-P
IHC-Fr
IF
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Nucleus
Tissue SpecificityExpressed in all adult tissues, with 5-fold lower levels observed in the brain.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017]
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human PAK3
Antigen Species
Human
Gene Name
PAK3
Gene ID
5063
Protein Name
Serine/threonine-protein kinase PAK 3
Uniprot ID
O75914
Function
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex
.
Chemical Properties
Molecular WeightTheoretical: 62 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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