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ML 083

🥰Excellent
Catalog No. T210540Cas No. 562867-96-3
Alias ML-083, ML083, ML 083, BML-283, BML283

ML 083 is a highly specific allosteric activator of the tumor-associated M2 isoform of human pyruvate kinase that modulates phosphoenolpyruvate binding cooperativity, and it is used as a metabolic research tool to investigate tumor-specific glycolytic regulation and cancer-associated metabolic reprogramming.

ML 083

ML 083

🥰Excellent
Purity: 99.99%
Catalog No. T210540Alias ML-083, ML083, ML 083, BML-283, BML283Cas No. 562867-96-3
ML 083 is a highly specific allosteric activator of the tumor-associated M2 isoform of human pyruvate kinase that modulates phosphoenolpyruvate binding cooperativity, and it is used as a metabolic research tool to investigate tumor-specific glycolytic regulation and cancer-associated metabolic reprogramming.
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Purity:99.99%
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Product Introduction

Bioactivity
Description
ML 083 is a highly specific allosteric activator of the tumor-associated M2 isoform of human pyruvate kinase that modulates phosphoenolpyruvate binding cooperativity, and it is used as a metabolic research tool to investigate tumor-specific glycolytic regulation and cancer-associated metabolic reprogramming.
In vitro
Method: Allosteric activators of human pyruvate kinase M2 were characterized using biochemical assays assessing PEP and ADP binding.
Result: ML 083 and ML082 selectively activated PK-M2 by enhancing PEP binding cooperativity with minimal effects on ADP binding[1].
SynonymsML-083, ML083, ML 083, BML-283, BML283
Chemical Properties
Molecular Weight454.52
FormulaC19H22N2O7S2
Cas No.562867-96-3
SmilesO=S(=O)(C1=CC=C(OC)C=C1)N2CCN(CC2)S(=O)(=O)C3=CC=C4OCCOC4=C3
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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