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ML 083
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Catalog No. T210540Cas No. 562867-96-3
Alias ML-083, ML083, ML 083, BML-283, BML283
ML 083 is a highly specific allosteric activator of the tumor-associated M2 isoform of human pyruvate kinase that modulates phosphoenolpyruvate binding cooperativity, and it is used as a metabolic research tool to investigate tumor-specific glycolytic regulation and cancer-associated metabolic reprogramming.
ML 083
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Purity: 99.99%
Catalog No. T210540Alias ML-083, ML083, ML 083, BML-283, BML283Cas No. 562867-96-3
ML 083 is a highly specific allosteric activator of the tumor-associated M2 isoform of human pyruvate kinase that modulates phosphoenolpyruvate binding cooperativity, and it is used as a metabolic research tool to investigate tumor-specific glycolytic regulation and cancer-associated metabolic reprogramming.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | - | In Stock | |
| 5 mg | $483 | - | In Stock | |
| 10 mg | $691 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,960 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.99%
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Product Introduction
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Chemical Properties
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| Description | ML 083 is a highly specific allosteric activator of the tumor-associated M2 isoform of human pyruvate kinase that modulates phosphoenolpyruvate binding cooperativity, and it is used as a metabolic research tool to investigate tumor-specific glycolytic regulation and cancer-associated metabolic reprogramming. |
| In vitro | Method: Allosteric activators of human pyruvate kinase M2 were characterized using biochemical assays assessing PEP and ADP binding. Result: ML 083 and ML082 selectively activated PK-M2 by enhancing PEP binding cooperativity with minimal effects on ADP binding[1]. |
| Synonyms | ML-083, ML083, ML 083, BML-283, BML283 |
| Molecular Weight | 454.52 |
| Formula | C19H22N2O7S2 |
| Cas No. | 562867-96-3 |
| Smiles | O=S(=O)(C1=CC=C(OC)C=C1)N2CCN(CC2)S(=O)(=O)C3=CC=C4OCCOC4=C3 |
| Color | White |
| Appearance | Solid |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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