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Lenalidomide-6-F

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Catalog No. T40129Cas No. 2468780-87-0

Lenalidomide-6-F is a derivative of Lenalidomide that serves as a cereblon (CRBN) ligand facilitating the recruitment of CRBN protein. With the addition of a linker, Lenalidomide-6-F can be conjugated to the ligand for the protein, enabling the formation of PROTAC.

Lenalidomide-6-F

Lenalidomide-6-F

😃Good
Catalog No. T40129Cas No. 2468780-87-0
Lenalidomide-6-F is a derivative of Lenalidomide that serves as a cereblon (CRBN) ligand facilitating the recruitment of CRBN protein. With the addition of a linker, Lenalidomide-6-F can be conjugated to the ligand for the protein, enabling the formation of PROTAC.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mgInquiry7-10 days7-10 days
100 mgInquiry7-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Lenalidomide-6-F is a derivative of Lenalidomide that serves as a cereblon (CRBN) ligand facilitating the recruitment of CRBN protein. With the addition of a linker, Lenalidomide-6-F can be conjugated to the ligand for the protein, enabling the formation of PROTAC.
In vitro
PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting two distinct ligands via a linker: one ligand targets an E3 ubiquitin ligase, while the other targets the desired protein[2].
Chemical Properties
Molecular Weight262.24
FormulaC13H11FN2O3
Cas No.2468780-87-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

Lenalidomide-6-FLenalidomide6FLenalidomide 6 F
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