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Anti-IL-36RN/IL-1F5 Antibody (3F415)

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Catalog No. TMAY-00310
Alias RP23-176J12.6, interleukin 36 receptor antagonist, Il1hy1, Il-1h3, Fil1δ, Fil1delta, AI413231

Anti-IL-36RN/IL-1F5 Antibody (3F415) is a Rabbit antibody targeting IL-36RN/IL-1F5. Anti-IL-36RN/IL-1F5 Antibody (3F415) can be used in ELISA.

Anti-IL-36RN/IL-1F5 Antibody (3F415)

Anti-IL-36RN/IL-1F5 Antibody (3F415)

😃Good
Catalog No. TMAY-00310Alias RP23-176J12.6, interleukin 36 receptor antagonist, Il1hy1, Il-1h3, Fil1δ, Fil1delta, AI413231
Anti-IL-36RN/IL-1F5 Antibody (3F415) is a Rabbit antibody targeting IL-36RN/IL-1F5. Anti-IL-36RN/IL-1F5 Antibody (3F415) can be used in ELISA.
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100 μL$269 7-10 days
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Product Introduction

Bioactivity
Description
Anti-IL-36RN/IL-1F5 Antibody (3F415) is a Rabbit antibody targeting IL-36RN/IL-1F5. Anti-IL-36RN/IL-1F5 Antibody (3F415) can be used in ELISA.
AliasRP23-176J12.6, interleukin 36 receptor antagonist, Il1hy1, Il-1h3, Fil1δ, Fil1delta, AI413231
Ig Type
Monoclonal Rabbit IgG
Clone
3F415
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:5000-1:10000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human IL-1F5 (rh IL-1F5; TMPY-00847; Q9UBH0; Met1-Asp155).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundInterleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist, and interleukin-1 receptor type I (IL-1R1), which is present in epithelial barriers and takes part in the local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8, as the effects were not observed in SIGIRR-/- mice. In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human IL-1F5 protein (TMPY-00847)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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