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Anti-IL-36RN/IL-1F5 Antibody (3F415)
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Catalog No. TMAY-00310
Alias RP23-176J12.6, interleukin 36 receptor antagonist, Il1hy1, Il-1h3, Fil1δ, Fil1delta, AI413231
Anti-IL-36RN/IL-1F5 Antibody (3F415) is a Rabbit antibody targeting IL-36RN/IL-1F5. Anti-IL-36RN/IL-1F5 Antibody (3F415) can be used in ELISA.
Anti-IL-36RN/IL-1F5 Antibody (3F415)
Anti-IL-36RN/IL-1F5 Antibody (3F415)
😃Good
Catalog No. TMAY-00310Alias RP23-176J12.6, interleukin 36 receptor antagonist, Il1hy1, Il-1h3, Fil1δ, Fil1delta, AI413231
Anti-IL-36RN/IL-1F5 Antibody (3F415) is a Rabbit antibody targeting IL-36RN/IL-1F5. Anti-IL-36RN/IL-1F5 Antibody (3F415) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA Reactivity: Human |
| Alias | RP23-176J12.6, interleukin 36 receptor antagonist, Il1hy1, Il-1h3, Fil1δ, Fil1delta, AI413231 |
| Ig Type | Rabbit IgG |
| Clone | 3F415 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-1F5 (rh IL-1F5; TMPY-00847; Q9UBH0; Met1-Asp155). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist, and interleukin-1 receptor type I (IL-1R1), which is present in epithelial barriers and takes part in the local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8, as the effects were not observed in SIGIRR-/- mice. In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human IL-1F5 protein (TMPY-00847) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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