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Anti-IL-36RN/IL-1F5 Antibody (3F415) (Synonyms: RP23-176J12.6, interleukin 36 receptor antagonist, Il1hy1, Il...)

Name: Anti-IL-36RN/IL-1F5 Antibody (3F415)
Brand: TargetMol
SKU: TMAY-00310
Rating: 4.5 (1 reviews)

Catalog No. TMAY-00310 Copy Product Info

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Anti-IL-36RN/IL-1F5 Antibody (3F415) is a Rabbit antibody targeting IL-36RN/IL-1F5. Anti-IL-36RN/IL-1F5 Antibody (3F415) can be used in ELISA.

Anti-IL-36RN/IL-1F5 Antibody (3F415)

Copy Product Info

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Catalog No. TMAY-00310

Synonyms RP23-176J12.6, interleukin 36 receptor antagonist, Il1hy1, Il-1h3, Fil1δ, Fil1delta, AI413231

Anti-IL-36RN/IL-1F5 Antibody (3F415) is a Rabbit antibody targeting IL-36RN/IL-1F5. Anti-IL-36RN/IL-1F5 Antibody (3F415) can be used in ELISA.

Anti-IL-36RN/IL-1F5 Antibody
(3F415)

Pack Size	Price	USA Stock	Global Stock	Quantity
100 μL	$269	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-IL-36RN/IL-1F5 Antibody (3F415) is a Rabbit antibody targeting IL-36RN/IL-1F5. Anti-IL-36RN/IL-1F5 Antibody (3F415) can be used in ELISA.
Synonyms	RP23-176J12.6, interleukin 36 receptor antagonist, Il1hy1, Il-1h3, Fil1δ, Fil1delta, AI413231
Ig Type	Rabbit IgG
Clone	3F415
Reactivity	Human
Specificity	Human IL-36RN/IL-1F5 No cross-reactivity in ELISA with Human IL1a Human IL1B Human IL1RA Human IL1F6 Human IL1F8
Application	ELISA
Recommended Dose	ELISA: 1:5000-1:10000
Antibody Type	Monoclonal
Host Species	Rabbit
Construction	This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-1F5 (rh IL-1F5; TMPY-00847; Q9UBH0; Met1-Asp155).
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS
Research Background	Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist, and interleukin-1 receptor type I (IL-1R1), which is present in epithelial barriers and takes part in the local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8, as the effects were not observed in SIGIRR-/- mice. In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain.

Related Conjugates and Formulations

Conjucates

Unconjugated

Antigen Details

Immunogen	Recombinant Protein: Human IL-1F5 protein (TMPY-00847)
Antigen Species	Human

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.

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Keywords

AI-413231AI 413231

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