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IPI-9119

Catalog No. T36841 CAS 1346564-56-4

IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM).

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IPI-9119, CAS 1346564-56-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 163.00
5 mg	In stock	$ 413.00
10 mg	In stock	$ 618.00
25 mg	In stock	$ 985.00
50 mg	In stock	$ 1,330.00
100 mg	In stock	$ 1,790.00
500 mg	In stock	$ 3,590.00
1 mL * 10 mM (in DMSO)	In stock	$ 449.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM).
Targets&IC50	FASN:0.3 nM (IC50)
In vitro	IPI-9119 (0.05, 0.1, 0.25, 0.5, 5 μM; 6 days) inhibits AR-FL and AR-V7 protein expression. IPI-9119 (0.1, 0.5 μM; 6 days) inhibits cell growth and induces cell cycle arrest and apoptosis[1]. IPI-9119 inhibits FASN in cellular occupancy assays (IC50∼10nM) and shows more than 400-fold selectivity against several additional serine hydrolases[2].
In vivo	IPI-9119 inhibits tumor growth of castration-resistant prostate cancer in xenografts mouse models[1].

Molecular Weight	495.43
Formula	C24H19F2N5O5
CAS No.	1346564-56-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (191.75 mM), Sonication is recommended.

References and Literature

1. Giorgia Zadra, et al. Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):631-640. 2. Erin Broph, et al. Abstract 1891: Pharmacological target validation studies of fatty acid synthase in carcinoma using the potent, selective and orally bioavailable inhibitor IPI-9119.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Orally Active Compound Library Metabolism Compound Library Anti-Obesity Compound Library Bioactive Compounds Library Max Anti-Cancer Metabolism Compound Library Bioactive Compound Library

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Related compounds with same targets

Icariside E4 Praeruptorin B ACSS2-IN-2 Fatostatin TVB-3166 Lycorine Fas C-Terminal Tripeptide Acetate Hydroxycitric acid

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IPI-9119 1346564-56-4 Metabolism Fatty Acid Synthase IPI9119 castration-resistant AR-V7 AR-FL prostate Inhibitor LNCaP-95 inhibit 22Rv1 irreversible C4-2 LNCaP orally Fatty Acid Synthase (FASN) CRPC cancer IPI 9119 inhibitor

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