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Dulozafone

Name: Dulozafone
Brand: TargetMol
SKU: T68058
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68058Cas No. 75616-02-3

Alias F1933

Dulozafone (F1933) has an anti- showed anticonvulsant activity in a brain amygdala ignition model and protected fully ignited rats from generalized seizures.

Dulozafone

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Purity: 98.14%

Catalog No. T68058Alias F1933Cas No. 75616-02-3

Dulozafone (F1933) has an anti- showed anticonvulsant activity in a brain amygdala ignition model and protected fully ignited rats from generalized seizures.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$81	-	In Stock
5 mg	$202	-	In Stock
10 mg	$288	-	In Stock
25 mg	$453	-	In Stock
50 mg	$645	-	In Stock
100 mg	$882	-	In Stock
200 mg	$1,180	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.14%

Appearance:Oil

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Dulozafone (F1933) has an anti- showed anticonvulsant activity in a brain amygdala ignition model and protected fully ignited rats from generalized seizures.
In vivo	Dulozafone (F1933) protected fully kindled rats against generalized seizures but failed to suppress partial ictal events (amygdala after discharges and limbic seizures). The anticonvulsive action of F1933, administered at the ED100, was nearly reversed by the specific antagonist of benzodiazepine receptors; R015-1788 (Flumazenil), suggesting that the effect of F1933 is mediated by this receptor. These results also emphasize the usefulness of kindling to test antiepileptic drugs and to confirm their supposed profile of action.[1]
Synonyms	F1933

Chemical Properties

Molecular Weight	425.31
Formula	C₂₀H₂₂Cl₂N₂O₄
Cas No.	75616-02-3
Smiles	C(=O)(C1=C(N(C(CN(CCO)CCO)=O)C)C=CC(Cl)=C1)C2=C(Cl)C=CC=C2

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (141.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3512 mL	11.7561 mL	23.5123 mL	117.5613 mL
5 mM	0.4702 mL	2.3512 mL	4.7025 mL	23.5123 mL
10 mM	0.2351 mL	1.1756 mL	2.3512 mL	11.7561 mL
20 mM	0.1176 mL	0.5878 mL	1.1756 mL	5.8781 mL
50 mM	0.0470 mL	0.2351 mL	0.4702 mL	2.3512 mL
100 mM	0.0235 mL	0.1176 mL	0.2351 mL	1.1756 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc