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MS402

Name: MS402
Brand: TargetMol
SKU: T12112
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12112Cas No. 1672684-68-2

MS402 is a novel BD1-selective BET BrD inhibitor.

MS402

🥰Excellent

Purity: 99.72%

Catalog No. T12112Cas No. 1672684-68-2

MS402 is a novel BD1-selective BET BrD inhibitor.

Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$59	In Stock
25 mg	$119	In Stock
50 mg	$187	In Stock
100 mg	$319	In Stock
200 mg	$459	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Batch Information

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Purity:99.72%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	MS402 is a novel BD1-selective BET BrD inhibitor.
Targets&IC50	BRD4 BD2:718 nM (Ki), BRD4 BD1:77 nM (Ki), BRD3 BD1:110 nM (Ki), BRD3 BD2:200 nM (Ki), BRD2 BD2:240 nM (Ki), BRD2 BD1:83 nM (Ki)
In vitro	MS402 preferentially renders Brd4 binding to Th17 signature gene loci over those of housekeeping genes and reduces Brd4 recruitment of p-TEFb to phosphorylate and activate RNA polymerase II for transcription elongation. Show that MS402 prevents and ameliorates T-cell transfer-induced colitis in mice by blocking Th17 cell overdevelopment.

Chemical Properties

Molecular Weight	370.83
Formula	C₂₀H₁₉ClN₂O₃
Cas No.	1672684-68-2
Smiles	COc1ccc(NC(=O)c2ccc(NC3=C(C)C(=O)CC3)c(Cl)c2)cc1
Relative Density.	1.352 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (60.67 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6967 mL	13.4833 mL	26.9665 mL	134.8327 mL
5 mM	0.5393 mL	2.6967 mL	5.3933 mL	26.9665 mL
10 mM	0.2697 mL	1.3483 mL	2.6967 mL	13.4833 mL
20 mM	0.1348 mL	0.6742 mL	1.3483 mL	6.7416 mL
50 mM	0.0539 mL	0.2697 mL	0.5393 mL	2.6967 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc