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MS402

Name: MS402
Brand: TargetMol
SKU: T12112
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12112Cas No. 1672684-68-2

MS402 is a novel BD1-selective BET BrD inhibitor.

MS402

🥰Excellent

Purity: 99.72%

Catalog No. T12112Cas No. 1672684-68-2

MS402 is a novel BD1-selective BET BrD inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	In Stock	In Stock
10 mg	$56	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$185	In Stock	In Stock
100 mg	$297	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$40	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.72%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	MS402 is a novel BD1-selective BET BrD inhibitor.
Targets&IC50	BRD4 BD2:718 nM (Ki), BRD3 BD2:200 nM (Ki), BRD4 BD1:77 nM (Ki), BRD3 BD1:110 nM (Ki), BRD2 BD1:83 nM (Ki), BRD2 BD2:240 nM (Ki)
In vitro	MS402 preferentially renders Brd4 binding to Th17 signature gene loci over those of housekeeping genes and reduces Brd4 recruitment of p-TEFb to phosphorylate and activate RNA polymerase II for transcription elongation. Show that MS402 prevents and ameliorates T-cell transfer-induced colitis in mice by blocking Th17 cell overdevelopment.

Chemical Properties

Molecular Weight	370.83
Formula	C₂₀H₁₉ClN₂O₃
Cas No.	1672684-68-2
Smiles	COc1ccc(NC(=O)c2ccc(NC3=C(C)C(=O)CC3)c(Cl)c2)cc1
Relative Density.	1.352 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (60.67 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6967 mL	13.4833 mL	26.9665 mL	134.8327 mL
5 mM	0.5393 mL	2.6967 mL	5.3933 mL	26.9665 mL
10 mM	0.2697 mL	1.3483 mL	2.6967 mL	13.4833 mL
20 mM	0.1348 mL	0.6742 mL	1.3483 mL	6.7416 mL
50 mM	0.0539 mL	0.2697 mL	0.5393 mL	2.6967 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc