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QNZ

Name: QNZ
Brand: TargetMol
SKU: T6204
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6204Cas No. 545380-34-5

Alias EVP4593, CAY10470

QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.

QNZ

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Purity: 99.18%

Catalog No. T6204Alias EVP4593, CAY10470Cas No. 545380-34-5

QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$36	In Stock	In Stock
2 mg	$52	In Stock	In Stock
5 mg	$85	In Stock	In Stock
10 mg	$143	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$347	In Stock	In Stock
100 mg	$516	-	In Stock
200 mg	$748	-	In Stock
1 mL x 10 mM (in DMSO)	$94	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.18%

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
Targets&IC50	TNF-α:7 nM, NF-κB:11 nM (in human Jurkat cells transfected with pNFκB-Luc)
In vitro	Intraperitoneal injection of EVP4593 (1 mg/kg) in rats suppressed carrageenan-induced paw edema in a dose-dependent manner.
In vivo	In murine spleen cells stimulated by lipopolysaccharide, EVP4593 (IC50= nM) inhibits the production of TNF-α. In rat neutrophils, EVP4593 (10 nM) suppresses the upregulation of CSE expression induced by lipopolysaccharide. EVP4593 (40 nM) entirely inhibits the increase in the number and length of axons during laminin treatment in Schwann cell adhesion. Additionally, in IB4-negative neurons, EVP4593 (100 nM) blocks the induction effect of GRO/KC on K currents.
Synonyms	EVP4593, CAY10470

Chemical Properties

Molecular Weight	356.42
Formula	C₂₂H₂₀N₄O
Cas No.	545380-34-5
Smiles	Nc1ccc2ncnc(NCCc3ccc(Oc4ccccc4)cc3)c2c1
Relative Density.	1.275g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 250 mg/mL (701.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8057 mL	14.0284 mL	28.0568 mL	140.2839 mL
5 mM	0.5611 mL	2.8057 mL	5.6114 mL	28.0568 mL
10 mM	0.2806 mL	1.4028 mL	2.8057 mL	14.0284 mL
20 mM	0.1403 mL	0.7014 mL	1.4028 mL	7.0142 mL
50 mM	0.0561 mL	0.2806 mL	0.5611 mL	2.8057 mL
100 mM	0.0281 mL	0.1403 mL	0.2806 mL	1.4028 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc