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Tiliquinol

Name: Tiliquinol
Brand: TargetMol
SKU: T64352
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T64352Cas No. 5541-67-3

Alias NSC 130828

Tiliquinol (NSC-130828) (NSC-130828) is a non-absorbed luminal agent with anti-amoebic properties that is often used in conjunction with tibroquinol. It is commonly employed in the study and investigation of amebic liver abscesses.

Tiliquinol

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Purity: 99.74%

Catalog No. T64352Alias NSC 130828Cas No. 5541-67-3

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$32	In Stock	In Stock
50 mg	$48	In Stock	In Stock
100 mg	$72	In Stock	In Stock
500 mg	$159	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.74%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Tiliquinol AI Summary

Tiliquinol exhibits a broad spectrum of bioactivities across various assays and models. It has demonstrated the ability to inhibit ROR gamma transcriptional activity, delay death of malarial parasite plastid, support Schwann cell viability, induce DNA re-replication in various cell lines, inhibit human tyrosyl-DNA phosphodiesterase 1, and block entry of both Marburg and Ebola viruses. Additionally, it shows potency as a gametocytocidal compound. Despite its wide-ranging pharmacological effects, it exhibits relatively low potency in assays targeting receptors like DRD1, SLC6A2, and HRH3, as well as enzymes such as ACHE, MAOA, and PTGS1. Moreover, it shows both agonist and antagonist activities at receptors HTR2B and ADRA1A, albeit at low affinity. The compound also has notable effects on liver toxicity, including moderate and acute hepatotoxicity and granulomatous hepatitis, though it is not significantly associated with chronic liver disease or tumors. With a LogP of 2.38, Tiliquinol has moderate hydrophobicity, which, along with its pKa values, suggest it possesses properties that may influence its solubility, permeability, and interaction with biological targets. Specifically, it inhibits liver catechol-O-methyltransferase activity in Sprague-Dawley rats with an IC50 of 44668.36 nM. Overall, while Tiliquinol displays a variety of bioactivities and potential therapeutic effects, its relatively low potency in many of the tested assays warrants further investigation to optimize its pharmacological properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tiliquinol (NSC-130828) (NSC-130828) is a non-absorbed luminal agent with anti-amoebic properties that is often used in conjunction with tibroquinol. It is commonly employed in the study and investigation of amebic liver abscesses.
Synonyms	NSC 130828

Chemical Properties

Molecular Weight	159.18
Formula	C₁₀H₉NO
Cas No.	5541-67-3
Smiles	Cc1ccc(O)c2ncccc12

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (565.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (20.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.2822 mL	31.4110 mL	62.8220 mL	314.1098 mL
5 mM	1.2564 mL	6.2822 mL	12.5644 mL	62.8220 mL
10 mM	0.6282 mL	3.1411 mL	6.2822 mL	31.4110 mL
20 mM	0.3141 mL	1.5705 mL	3.1411 mL	15.7055 mL
50 mM	0.1256 mL	0.6282 mL	1.2564 mL	6.2822 mL
100 mM	0.0628 mL	0.3141 mL	0.6282 mL	3.1411 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc