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Pseudocoptisine chloride (Isocoptisine chloride) is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity (IC50 = 12.8 μM).

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $67 | In Stock | In Stock | |
| 5 mg | $163 | In Stock | In Stock | |
| 10 mg | $247 | In Stock | In Stock | |
| 25 mg | $463 | In Stock | In Stock | |
| 50 mg | $683 | In Stock | In Stock | |
| 100 mg | $967 | In Stock | In Stock |
| Description | Pseudocoptisine chloride (Isocoptisine chloride) is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity (IC50 = 12.8 μM). |
| Targets&IC50 | AChE:12.8 μM |
| In vitro | In RAW264.7 cells, Pseudocoptisine chloride (0, 60, 90 μM; 1 hour) inhibited LPS-induced NO production in a dose-dependent manner[1]. Pseudocoptisine chloride reduced levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation. Pseudocoptisine chloride (30-90 μM; 1 hour) significantly reduced the LPS-induced TNF-α and IL-6 production and their mRNA expressions[2]. |
| In vivo | Pseudocoptisine chloride (2.0 mg/kg, p.o.) showed anti-amnesic activities on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) and significantly reverses cognitive impairments in mice by passive avoidance test[2]. |
| Synonyms | Isocoptisine chloride |
| Molecular Weight | 355.77 |
| Formula | C19H14ClNO4 |
| Cas No. | 30044-78-1 |
| Smiles | [Cl-].C1Oc2cc3CC[n+]4cc5cc6OCOc6cc5cc4-c3cc2O1 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (2.81 mM), Sonication and heating to 60℃ are recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
| |||||||||||
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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