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Drug Metabolite

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom oxygenations, reductions, and dehydrogenations, heteroatom dealkylations, hydroxylations, can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

CLOZAPINE N-OXIDE
T449434233-69-7
Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.
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Homoeriodictyol
TN1740446-71-9
Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotonin release in differentiated Caco-2 cells.
  • $129
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Phosphoramide mustard
T3841010159-53-2
Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.
  • $293
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7-Hydroxymethotrexate
T203395939-37-7
7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibiting DNA synthesis.Methotrexate is also an inhibitor of metabolism.
  • $312
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Oseltamivir acid
T5186187227-45-8
Oseltamivir acid (GS4071) is a potent influenza virus neuraminidase inhibitor and the prodrug of GS4071.
  • $30
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Desmethyl Erlotinib
T6328183321-86-0
Desmethyl Erlotinib (CP-473420) is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
  • $48
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Linsidomine hydrochloride
T2335616142-27-1
Linsidomine hydrochloride (SIN-1 chloride) is considered as a metabolite of moxidomine, with vasodilation, inhibition of platelet aggregation, and antiangina activity. In myocardial ischemia-reperfusion models, Linsidomine hydrochloride to reduce myocardial necrosis and reperfusion induced endothelial dysfunction is associated with the cavernosal mechanism of action involved in nitric oxide release.
  • $64
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4-Hydroxymephenytoin
T1014761837-65-8In house
4-Hydroxymephenytoin ((+ -)-4'-Hydroxymephenytoin) is the metabolism of an antiepileptic drug mephenytoin. Mephenytoin is used as a CYP2C19 substrate.
  • $39
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S-methyl-KE-298
T4282143584-75-2
S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from  rheumatoid arthritis (RA) synovial cells.
  • $193
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Hydroxy Itraconazole
TQ0224112559-91-8
Hydroxy Itraconazole (R63373) is a triazole compound with antifungal activity for the study of malignant tumors.
  • $393
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Allopurinol riboside
T1353916220-07-8In house
Allopurinol riboside is a metabolite of allopurinol with potency against parasites. Allopurinol riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a Ki of 277 μM.
  • $31
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Leukotriene D4
T3812873836-78-9In house
Leukotriene D4 (LTD4) is a potent pro-inflammatory mediator formed from arachidonic acid, a bronchoconstrictor, and induces osteoclast senescence.Leukotriene D4 induces transcriptional activity of potentially oncogenic genes and can be used in the study of asthma.
  • $287
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Didesethyl chloroquine
T110394298-14-0In house
Didesethyl chloroquine (Bisdesethylchloroquine) is an effective myocardial inhibitor. Didesethyl chloroquine (Bisdesethylchloroquine) is the main metabolite of the antimalarial drug chloroquine.
  • $89
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CNDAC hydrochloride
T13621134665-72-8
CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.
  • $116
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N-Deshydroxyethyl Dasatinib
T18750910297-51-7
N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER. N-Deshydroxyethyl Dasatinib is used in the study of cancer and immune diseases.
  • $84
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DL-Laudanosine
T81751699-51-0
DL-Laudanosine (Laudanosine) is a recognized metabolite of atracurium and cisatracurium.
  • $42
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2-Hydroxy atorvastatin calcium salt
TQ0045265989-46-6In house
2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of atorvastatin calcium salt, a potent HMG-CoA reductase inhibitor (IC50 = 8 nM).
  • $182
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AST5902 mesylate(2412155-74-7 free base)
T8945L2412155-75-8
AST5902 mesylate is principal metabolite of Alflutinib in vivo. AST5902 mesylate exerts antineoplastic activity.
  • $137
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2′,2′-Difluorodeoxyuridine
T67291114248-23-6
2′,2′-Difluorodeoxyuridine (dFdU), the major metabolite of Gemcitabine, exhibits anticancer and antitumor activities, shows radiosensitization under hypoxic conditions, and can be used to study pancreatic cancer.
  • $34
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4-hydroperoxy cyclophosphamide
T3564339800-16-3
4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.4-Hydroperoxy cyclophosphamide increases levels of glutaminase and aspartate aminotransferase, enhances inflammatory factors and oxidative markers, and Inhibits oxidoreductase activity.4-Hydroperoxy cyclophosphamide is used in the study of cancer and autoimmune diseases.
  • $230
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Deslanoside
T818317598-65-1
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias associated with reentry mechanisms. It inhibits the Na-K-ATPase membrane pump, increasing intracellular sodium and calcium concentrations.
  • $80
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Clofibric acid
T0061882-09-7
Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
  • $31
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meta-Fexofenadine
T12005479035-75-1
meta-Fexofenadine (meta-MDL-16455) is an isomer of Fexofenadine.
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4-Methylamino antipyrine
T10152519-98-2
4-Methylamino antipyrine, an active metabolite of Metamizole, a pyrazolone non-steroidal anti-inflammatory drug (NSAID) that inhibits COX, possesses analgesic, antipyretic, and relatively weak anti-inflammatory properties.
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AZ7550
T135641421373-99-0
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
  • $133
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N-Acetylprocainamide
T024932795-44-1
N-Acetylprocainamide (NAPA), the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic drug.
  • $29
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N-Desmethyl imatinib
T11641404844-02-6
N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
  • $84
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Enzalutamide carboxylic acid
T82171242137-15-0
Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
  • $60
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Palifosfamide
T435031645-39-3
Palifosfamide (Isophosphamide mustard) lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to 6.75 μM for most cell lines except OS222 (IC50=31.5 μM).
  • $70
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5-Hydroxylansoprazole
T14051131926-98-2
5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole, a gastric proton-pump inhibitor used to treat various peptic diseases. Lansoprazole is metabolized through CYP2C19, resulting in the formation of 5-Hydroxylansoprazole[1][2].
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    Dehydro Nifedipine
    T3666567035-22-7
    Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is metabolized by cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5.
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    Ferulic acid 4-O-sulfate
    T7457986321-29-1
    Ferulic acid 4-O-sulfate (Ferulic acid 4-sulfate) is a metabolite of Ferulic acid.Ferulic acid 4-O-sulfate relaxes arteries, lowers blood pressure, and resists oxidative stress under conditions of iron overload in mice and HepG2 cells.Ferulic acid 4-O-sulfate is a metabolite of Ferulic acid.
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    Desmethyl Erlotinib hydrochloride
    T6619183320-51-6
    Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells.
    • $54
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    Nortriptyline hydrochloride
    T1327894-71-3
    Nortriptyline hydrochloride (ELF-101 hydrochloride) is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
    • $33
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    N-desmethyl Olanzapine
    T35716161696-76-0
    N-desmethyl Olanzapine is a metabolite of the atypical antipsychotic compound Olanzapinec, which is formed through the oxidative metabolism of olanzapine by the cytochrome 450 (CYP) isoenzyme CYP1A2.
    • $35
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    Homovanillyl alcohol
    TN17422380-78-1
    Homovanillyl alcohol, a biological metabolite of Hydroxytyrosol, is a phenolic compound found in virgin olive oil (VOO) and wine. It exhibits high scavenging activities, protects red blood cells from hemolysis in a dose-dependent manner, and has a protective effect on cardiovascular disease and total mortality.
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    N-Desethyl Sunitinib hydrochloride
    T74127
    N-Desethyl Sunitinib hydrochloride (SU-12662 hydrochloride) is an active metabolite of Sunitinib with potential anti-cancer activity for the study of cancer.
    • $150
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    Norverapamil hydrochloride
    T1633967812-42-4
    Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
    • $31
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    IMR-1A
    T3540331862-41-0
    IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
    • $68
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    Regorafénib N-oxyde (M2)
    T10157835621-11-9
    Regorafénib N-oxyde M2 is an active metabolite of Regorafenib, a multi-target inhibitor for VEGFR1 2 3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13 4.2 46, 1.5, 22, 7, and 2.5 nM).
    • $37
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    Monoethyl phthalate
    T398362306-33-4
    Monoethyl phthalate, a metabolite of diethyl phthalate, serves as a urinary biomarker for phthalate exposure and indicates potential risks of thyroid cancer and benign nodules.
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    Endoxifen hydrochloride
    T6827L1197194-41-4In house
    Endoxifen hydrochloride, a principal active metabolite of Tamoxifen (TAM), exhibits heightened affinity and specificity towards the estrogen receptor and possesses aromatase inhibitory capability. It holds promise for breast cancer research.
    • $41
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    GS-829845
    T679051257705-09-1In house
    GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life than the parent.
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    Imidacloprid-urea
    T72077120868-66-8
    Imidacloprid-urea is a secondary metabolite of imidacloprid. Imidacloprid is a potent and widely used neonicotinoid with inhibitory effects on pests of cereals, vegetables, tea and cotton. imidacloprid-urea can occupy or block the adsorption sites of imidacloprid on the soil, which may affect the fate, transport and bioavailability of imidacloprid in the environment.
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    Cycloguanil hydrochloride
    T5420152-53-4
    Cycloguanil hydrochloride (Chloroguanide Triazine) is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms, respectively).
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    Etilevodopa hydrochloride
    T2404739740-30-2
    Etilevodopa hydrochloride (L-DOPA ethyl ester) is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration.
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    Acetylsulfamerazine
    T72042127-73-1
    Acetylsulfamerazine (N-Acetylsulfamerazine) is a secondary metabolite of sulphamethazine, which has a slight inhibitory effect on cellulose digestion and rumen endocrine activity, and has anti-microbial activity.
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    Hydroxy Dimetridazole
    T37514936-05-0
    Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity. It was once widely used in the treatment of parasitic infections in poultry, cattle, swine and farmed fish until suspected to be carcinogenic and mutagenic to humans. Hydroxy dimetridazole is a metabolite of dimetridazole that may be useful for identifying this nitroimidazole in various agricultural samples through liquid chromatography-tandem mass spectrometry and other methods.
    • $59
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