Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Drug Metabolite

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom oxygenations, reductions, and dehydrogenations, heteroatom dealkylations, hydroxylations, can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Clozapine N-Oxide
T449434233-69-7
Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Hot
Leukotriene D4
T3812873836-78-9In house
Leukotriene D4 (LTD4) is a potent pro-inflammatory mediator formed from arachidonic acid, a bronchoconstrictor, and induces osteoclast senescence.Leukotriene D4 induces transcriptional activity of potentially oncogenic genes and can be used in the study of asthma.
  • $287
In Stock
Size
QTY
Linsidomine hydrochloride
T2335616142-27-1
Linsidomine hydrochloride (SIN-1 chloride) is considered as a metabolite of moxidomine, with vasodilation, inhibition of platelet aggregation, and antiangina activity. In myocardial ischemia-reperfusion models, Linsidomine hydrochloride to reduce myocardial necrosis and reperfusion induced endothelial dysfunction is associated with the cavernosal mechanism of action involved in nitric oxide release.
  • $64
In Stock
Size
QTY
Homoeriodictyol
TN1740446-71-9
Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotonin release in differentiated Caco-2 cells.
  • $129
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Hydroxy Itraconazole
TQ0224112559-91-8
Hydroxy Itraconazole (R63373) is a triazole compound with antifungal activity for the study of malignant tumors.
  • $156
In Stock
Size
QTY
4-Hydroxymephenytoin
T1014761837-65-8In house
4-Hydroxymephenytoin ((+ -)-4'-Hydroxymephenytoin) is the metabolism of an antiepileptic drug mephenytoin. Mephenytoin is used as a CYP2C19 substrate.
  • $39
In Stock
Size
QTY
Phosphoramide mustard
T3841010159-53-2
Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.
  • $293
In Stock
Size
QTY
Niraparib metabolite M1
T122291476777-06-6In house
Niraparib metabolite M1 (Niraparib carboxylic acid metabolite M1) is the carboxylic acid metabolite of Niraparib. Niraparib is a novel poly (ADP-ribose) polymerase (PARP) inhibitor used in cancer research.
  • $152
In Stock
Size
QTY
Oseltamivir acid
T5186187227-45-8
Oseltamivir acid (GS4071) is a potent influenza virus neuraminidase inhibitor and the prodrug of GS4071.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
7-Hydroxymethotrexate
T203395939-37-7
7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibiting DNA synthesis.Methotrexate is also an inhibitor of metabolism.
  • $312
In Stock
Size
QTY
Mycophenolate Mofetil
T6293128794-94-5
Mycophenolate Mofetil (TM-MMF), an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH).
  • $35
In Stock
Size
QTY
4-hydroperoxy cyclophosphamide
T3564339800-16-3
4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.4-Hydroperoxy cyclophosphamide increases levels of glutaminase and aspartate aminotransferase, enhances inflammatory factors and oxidative markers, and Inhibits oxidoreductase activity.4-Hydroperoxy cyclophosphamide is used in the study of cancer and autoimmune diseases.
  • $333
In Stock
Size
QTY
S-methyl-KE-298
T4282143584-75-2
S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from  rheumatoid arthritis (RA) synovial cells.
  • $95
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Deslanoside
T818317598-65-1
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias associated with reentry mechanisms. It inhibits the Na-K-ATPase membrane pump, increasing intracellular sodium and calcium concentrations.
  • $80
In Stock
Size
QTY
p-Coumaric Acid Ethyl Ester
T138087362-39-2
p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate) is the ethyl ester of p-Coumaric acid. p-Coumaric Acid is a common dietary polyphenol and also a potent immunosuppressive agent in treating autoimmune inflammatory diseases like rheumatoid arthritis.
  • $42
In Stock
Size
QTY
Desmethyl Erlotinib
T6328183321-86-0
Desmethyl Erlotinib (CP-473420) is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
  • $48
In Stock
Size
QTY
Dehydro Nifedipine
T3666567035-22-7
Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is metabolized by cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5.
  • $42
In Stock
Size
QTY
Didesethyl chloroquine
T110394298-14-0In house
Didesethyl chloroquine (Bisdesethylchloroquine) is an effective myocardial inhibitor. Didesethyl chloroquine (Bisdesethylchloroquine) is the main metabolite of the antimalarial drug chloroquine.
  • $53
In Stock
Size
QTY
TargetMol | Inhibitor Sale
N-Deshydroxyethyl Dasatinib
T18750910297-51-7
N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER. N-Deshydroxyethyl Dasatinib is used in the study of cancer and immune diseases.
  • $84
In Stock
Size
QTY
TargetMol | Inhibitor Sale
3-Sulfopropanoic acid
TN724644826-45-1
3-Sulfopropanoic acid, a major metabolite of treprostinil and its prodrug ALZ-801, is an endogenous molecule present in the cerebrospinal fluid (CSF) of AD patients that inhibits the formation of Aβ42 oligomers.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
DL-Laudanosine
T81751699-51-0
DL-Laudanosine (Laudanosine) is a recognized metabolite of atracurium and cisatracurium.
  • $42
In Stock
Size
QTY
N-Desmethylclozapine
T51586104-71-8
N-Desmethylclozapine (Desmethylclozapine) is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors.
  • $30
In Stock
Size
QTY
2-Hydroxy atorvastatin calcium salt
TQ0045265989-46-6In house
2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of atorvastatin calcium salt, a potent HMG-CoA reductase inhibitor (IC50 = 8 nM).
  • $182
In Stock
Size
QTY
Regorafénib N-oxyde (M2)
T10157835621-11-9
Regorafénib N-oxyde M2 is an active metabolite of Regorafenib, a multi-target inhibitor for VEGFR1 2 3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13 4.2 46, 1.5, 22, 7, and 2.5 nM).
  • $37
In Stock
Size
QTY
TargetMol | Inhibitor Sale