Shopping Cart

Your shopping cart is currently empty

K67

Name: K67
Brand: TargetMol
SKU: T27709
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T27709Cas No. 2046250-48-8

Alias K-67, K 67

K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1, inhibits the proliferation of HCC cells with high expression of S351 phosphorylated p62, and can be used to study cancer.

K67

🥰Excellent

Purity: 98.43%

Catalog No. T27709Alias K-67, K 67Cas No. 2046250-48-8

K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1, inhibits the proliferation of HCC cells with high expression of S351 phosphorylated p62, and can be used to study cancer.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$149	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.43%

Resource Download

COA

Product Introduction

Bioactivity

Description	K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1, inhibits the proliferation of HCC cells with high expression of S351 phosphorylated p62, and can be used to study cancer.
In vitro	METHODS: Huh7 cells expressing S351E were treated with K67 (50 μM, 4 h), and the cells were treated with or without lactacystin (10 μM) for 8 hours. Immunoblot analyses were performed for immunosuppressants with anti-Nrf2 antibodies. RESULTS:Treatment of Huh1 cells with K67 greatly inhibited the interaction between p62 phosphorylation and Keap1, and K67 significantly promoted ubiquitination of Nrf2. [1]
Synonyms	K-67, K 67

Chemical Properties

Molecular Weight	582.69
Formula	C₂₉H₃₀N₂O₇S₂
Cas No.	2046250-48-8
Smiles	O=C(C)CC=1C=C(NS(=O)(=O)C2=CC=C(OCC)C=C2)C=3C=CC=CC3C1NS(=O)(=O)C4=CC=C(OCC)C=C4
Relative Density.	1.357 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (137.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (8.58 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7162 mL	8.5809 mL	17.1618 mL	85.8089 mL
5 mM	0.3432 mL	1.7162 mL	3.4324 mL	17.1618 mL
10 mM	0.1716 mL	0.8581 mL	1.7162 mL	8.5809 mL
20 mM	0.0858 mL	0.4290 mL	0.8581 mL	4.2904 mL
50 mM	0.0343 mL	0.1716 mL	0.3432 mL	1.7162 mL
100 mM	0.0172 mL	0.0858 mL	0.1716 mL	0.8581 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc