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K67

Name: K67
Brand: TargetMol
SKU: T27709
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27709Cas No. 2046250-48-8

Alias K-67, K 67

K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1, inhibits the proliferation of HCC cells with high expression of S351 phosphorylated p62, and can be used to study cancer.

K67

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Purity: 98.43%

Catalog No. T27709Alias K-67, K 67Cas No. 2046250-48-8

K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1, inhibits the proliferation of HCC cells with high expression of S351 phosphorylated p62, and can be used to study cancer.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.43%

Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1, inhibits the proliferation of HCC cells with high expression of S351 phosphorylated p62, and can be used to study cancer.
In vitro	METHODS: Huh7 cells expressing S351E were treated with K67 (50 μM, 4 h), and the cells were treated with or without lactacystin (10 μM) for 8 hours. Immunoblot analyses were performed for immunosuppressants with anti-Nrf2 antibodies. RESULTS:Treatment of Huh1 cells with K67 greatly inhibited the interaction between p62 phosphorylation and Keap1, and K67 significantly promoted ubiquitination of Nrf2. [1]
Synonyms	K-67, K 67

Chemical Properties

Molecular Weight	582.69
Formula	C₂₉H₃₀N₂O₇S₂
Cas No.	2046250-48-8
Smiles	O=C(C)CC=1C=C(NS(=O)(=O)C2=CC=C(OCC)C=C2)C=3C=CC=CC3C1NS(=O)(=O)C4=CC=C(OCC)C=C4
Relative Density.	1.357 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (137.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (8.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7162 mL	8.5809 mL	17.1618 mL	85.8089 mL
5 mM	0.3432 mL	1.7162 mL	3.4324 mL	17.1618 mL
10 mM	0.1716 mL	0.8581 mL	1.7162 mL	8.5809 mL
20 mM	0.0858 mL	0.4290 mL	0.8581 mL	4.2904 mL
50 mM	0.0343 mL	0.1716 mL	0.3432 mL	1.7162 mL
100 mM	0.0172 mL	0.0858 mL	0.1716 mL	0.8581 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc