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Benzonitrile, 3,3'-[(2-oxo-1,3-cyclohexanediylidene)dimethylidyne]bis-

🥰Excellent
Catalog No. T9129Cas No. 63476-70-0

Benzonitrile, 3,3'-[(2-oxo-1,3-cyclohexanediylidene)dimethylidyne]bis- is an inhibitor of p53 with an IC50 value of 0.35 μM

Benzonitrile, 3,3'-[(2-oxo-1,3-cyclohexanediylidene)dimethylidyne]bis-

Benzonitrile, 3,3'-[(2-oxo-1,3-cyclohexanediylidene)dimethylidyne]bis-

🥰Excellent
Purity: 99.18%
Catalog No. T9129Cas No. 63476-70-0
Benzonitrile, 3,3'-[(2-oxo-1,3-cyclohexanediylidene)dimethylidyne]bis- is an inhibitor of p53 with an IC50 value of 0.35 μM
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$44In StockIn Stock
5 mg$109In StockIn Stock
10 mg$161In StockIn Stock
25 mg$273In StockIn Stock
50 mg$393In StockIn Stock
100 mg$551In StockIn Stock
200 mg$748In StockIn Stock
1 mL x 10 mM (in DMSO)$113In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.18%
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COA HNMR HPLC LCMS

Product Introduction

Bioactivity
Description
Benzonitrile, 3,3'-[(2-oxo-1,3-cyclohexanediylidene)dimethylidyne]bis- is an inhibitor of p53 with an IC50 value of 0.35 μM
Targets&IC50
p53:0.35 μM
Chemical Properties
Molecular Weight324.38
FormulaC22H16N2O
Cas No.63476-70-0
SmilesC(=C1C(=O)C(=CC2=CC(C#N)=CC=C2)CCC1)C3=CC(C#N)=CC=C3
Relative Density.1.22 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 11 mg/mL (33.91 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0828 mL15.4140 mL30.8280 mL154.1402 mL
5 mM0.6166 mL3.0828 mL6.1656 mL30.8280 mL
10 mM0.3083 mL1.5414 mL3.0828 mL15.4140 mL
20 mM0.1541 mL0.7707 mL1.5414 mL7.7070 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

p53Benzonitrile, 3,3'[(2oxo1,3cyclohexanediylidene)dimethylidyne]bisBenzonitrile, 3,3' [(2 oxo 1,3 cyclohexanediylidene)dimethylidyne]bis
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