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ML359

Name: ML359
Brand: TargetMol
SKU: T25821
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25821Cas No. 1069858-99-6

Alias ML-359, ML 359

ML359 is a protein disulfide isomerase inhibitor.

ML359

😃Good

Purity: 99.68%

Catalog No. T25821Alias ML-359, ML 359Cas No. 1069858-99-6

ML359 is a protein disulfide isomerase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$81	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$317	In Stock	In Stock
25 mg	$553	In Stock	In Stock
50 mg	$782	In Stock	In Stock
100 mg	$1,090	-	In Stock
1 mL x 10 mM (in DMSO)	$217	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.68%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	ML359 is a protein disulfide isomerase inhibitor.
Targets&IC50	Protein disulfide isomerase:250 nM (IC50)
In vitro	ML359 shown to be a specific inhibitor of PDI.?ML359 shows no cytotoxicity in three human cell lines, and some activity in inhibiting platelet aggregation in vitro.?ML359 will provide more understanding of the mechanisms of PDI in platelet functions.?It also could lead to the development of a new class of antithrombotics that could establish PDI as suitable drug target.
Synonyms	ML-359, ML 359

Chemical Properties

Molecular Weight	417.93
Formula	C₂₃H₂₈ClNO₄
Cas No.	1069858-99-6
Smiles	CCOC(=O)C1(CCOc2ccccc2)CCN(Cc2ccc(O)c(Cl)c2)CC1
Relative Density.	1.212 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 84 mg/mL (200.99 mM), Sonication is recommended.

Ethanol: 84 mg/mL (200.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.3927 mL	11.9637 mL	23.9275 mL	119.6373 mL
5 mM	0.4785 mL	2.3927 mL	4.7855 mL	23.9275 mL
10 mM	0.2393 mL	1.1964 mL	2.3927 mL	11.9637 mL
20 mM	0.1196 mL	0.5982 mL	1.1964 mL	5.9819 mL
50 mM	0.0479 mL	0.2393 mL	0.4785 mL	2.3927 mL
100 mM	0.0239 mL	0.1196 mL	0.2393 mL	1.1964 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc