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ML359

Name: ML359
Brand: TargetMol
SKU: T25821
Price: 83 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T25821Cas No. 1069858-99-6

Alias ML-359, ML 359

ML359 is a protein disulfide isomerase inhibitor.

ML359

🥰Excellent

Purity: 99.68%

Catalog No. T25821Alias ML-359, ML 359Cas No. 1069858-99-6

ML359 is a protein disulfide isomerase inhibitor.

Pack Size	Price	Availability
1 mg	$83	In Stock
5 mg	$197	In Stock
10 mg	$332	In Stock
25 mg	$558	In Stock
50 mg	$788	In Stock
100 mg	$1,120	In Stock
1 mL x 10 mM (in DMSO)	$232	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.68%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	ML359 is a protein disulfide isomerase inhibitor.
Targets&IC50	Protein disulfide isomerase:250 nM (IC50)
In vitro	ML359 shown to be a specific inhibitor of PDI.?ML359 shows no cytotoxicity in three human cell lines, and some activity in inhibiting platelet aggregation in vitro.?ML359 will provide more understanding of the mechanisms of PDI in platelet functions.?It also could lead to the development of a new class of antithrombotics that could establish PDI as suitable drug target.
Synonyms	ML-359, ML 359

Chemical Properties

Molecular Weight	417.93
Formula	C₂₃H₂₈ClNO₄
Cas No.	1069858-99-6
Smiles	CCOC(=O)C1(CCOc2ccccc2)CCN(Cc2ccc(O)c(Cl)c2)CC1
Relative Density.	1.212 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 84 mg/mL (200.99 mM), Sonication is recommended.

Ethanol: 84 mg/mL (200.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.3927 mL	11.9637 mL	23.9275 mL	119.6373 mL
5 mM	0.4785 mL	2.3927 mL	4.7855 mL	23.9275 mL
10 mM	0.2393 mL	1.1964 mL	2.3927 mL	11.9637 mL
20 mM	0.1196 mL	0.5982 mL	1.1964 mL	5.9819 mL
50 mM	0.0479 mL	0.2393 mL	0.4785 mL	2.3927 mL
100 mM	0.0239 mL	0.1196 mL	0.2393 mL	1.1964 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc