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L82

Catalog No. T60753 CAS 329227-30-7

L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.

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L82, CAS 329227-30-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 64.00
10 mg	In stock	$ 105.00
25 mg	In stock	$ 197.00
50 mg	In stock	$ 313.00
100 mg	In stock	$ 497.00
500 mg	In stock	$ 1,080.00
1 mL * 10 mM (in DMSO)	In stock	$ 70.00

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Purity: 99.07%

Purity: 98.91%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.
Targets&IC50	DNA ligase I:12 μM
In vitro	L82 (0-50 μM; 6 d) reduced the proliferation of a normal breast epithelial cell line MCF10A and the breast cancer cell lines MCF7, HeLa, and HCT116 in a concentration-dependent manner.[2] L82 (50 μM; 0-48 h) shows cytostatic activity due to activation of the G1/S checkpoint in MCF7 cells.[2]

Molecular Weight	309.67
Formula	C11H8ClN5O4
CAS No.	329227-30-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30.0 mg/mL (96.9 mM), Sonication is recommended.

References and Literature

1. Howes TRL, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017;60:29-39. 2. Chen X, et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008;68(9):3169-3177. 3. Stowers RS, et al. The 82F late puff contains the L82 gene, an essential member of a novel gene family. Dev Biol. 1999;213(1):116-130.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max

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Keywords

L82 329227-30-7 DNA Damage/DNA Repair DNA inhibitor inhibit

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