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Btk inhibitor 2

Name: Btk inhibitor 2
Brand: TargetMol
SKU: T10629
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10629Cas No. 1558036-85-3

Alias BGB-3111 analog

Btk Inhibitor 2 (BGB-3111 analog) is a BTK inhibitor.

Btk inhibitor 2

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Purity: 99.94%

Catalog No. T10629Alias BGB-3111 analogCas No. 1558036-85-3

Btk Inhibitor 2 (BGB-3111 analog) is a BTK inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
2 mg	$44	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$105	In Stock	In Stock
25 mg	$239	In Stock	In Stock
50 mg	$396	In Stock	In Stock
100 mg	$482	-	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Btk inhibitor 2 AI Summary

Btk inhibitor 2 shows potent bioactivity as a BTK inhibitor, demonstrating an IC50 of 0.17 nM for inhibiting recombinant BTK activity in a TR-FRET assay and an IC50 of 1.0 nM for reducing BTK phosphorylation at the Tyr223 residue in human Ramos cells when stimulated with pervanadate or Na3VO4. Additionally, this compound exhibits antiviral activity by inhibiting the SARS-CoV-2 3CL-Pro protease by 16.58% at a concentration of 20 µM in a FRET assay and shows an inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 µM after 48 hours at 0.01 MOI SARS-CoV-2 virus, with a measured inhibition of -0.27%. These results indicate its potential as a targeted therapy for BTK-related diseases and as an antiviral agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Btk Inhibitor 2 (BGB-3111 analog) is a BTK inhibitor.
Synonyms	BGB-3111 analog

Chemical Properties

Molecular Weight	431.49
Formula	C₂₄H₂₅N₅O₃
Cas No.	1558036-85-3
Smiles	NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Relative Density.	1.32 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 75 mg/mL (173.82 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3176 mL	11.5878 mL	23.1755 mL	115.8775 mL
5 mM	0.4635 mL	2.3176 mL	4.6351 mL	23.1755 mL
10 mM	0.2318 mL	1.1588 mL	2.3176 mL	11.5878 mL
20 mM	0.1159 mL	0.5794 mL	1.1588 mL	5.7939 mL
50 mM	0.0464 mL	0.2318 mL	0.4635 mL	2.3176 mL
100 mM	0.0232 mL	0.1159 mL	0.2318 mL	1.1588 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc