IL-17F Protein, Human, Recombinant

Name: IL-17F Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPJ-00046
Rating: 4.5 (1 reviews)

(Synonyms: Interleukin-17F, IL-17F, IL17F, Cytokine ML-1) Copy Product Info

Synonyms: Interleukin-17F, IL-17F, IL17F, Cytokine ML-1

Catalog No. TMPJ-00046 Copy Product Info

Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Today, IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.

Pack Size	Price	USA Stock	Global Stock
5 µg	$88	35 days	35 days
10 µg	$143	35 days	35 days
20 µg	$229	35 days	35 days
50 µg	$433	35 days	35 days
100 µg	$675	35 days	35 days
200 µg	$1,050	35 days	35 days
500 µg	$1,900	35 days	35 days
1 mg	$2,730	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	1. Loaded Biotinylated Human IL-17RA-His-Avi on HIS1K Biosensor, can bind Human IL-17F with an affinity constant of 0.56 uM nM as determined in BLI assay. (Regularly tested) 2. Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 5-40 ng/ml. (QC verified) 3. Immobilized Human IL-17F at 2μg/ml (100 μl/well)can bind Biotinylated Human IL-17RA-His-Avi. The ED50 of Biotinylated Human IL-17RA-His-Avi is 0.11 ug/ml. (Regularly tested)
Description	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Today, IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	Q96PD4
Amino Acid	Arg31-Gln163
Construction	Arg31-Gln163
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	Interleukin-17F, IL-17F, IL17F, Cytokine ML-1
Research Background	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Today, IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.

Chemical Properties

Molecular Weight

15 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.