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NSC 80467
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Catalog No. T38414Cas No. 101982-51-8
Alias NSC80467
NSC 80467 is a selective DNA-damaging agent that functions through survivin inhibition. NSC 80467 preferentially disrupts DNA synthesis, thereby inducing two hallmark DNA-damage markers, γH2AX and pKAP1. NSC 80467 enables mechanistic investigation in to DNA replication stress and apoptosis-associated signaling pathways and serves as a biochemical tool for evaluating survivin-dependent cellular processes in oncology research.
NSC 80467
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Purity: 99.25%
Catalog No. T38414Alias NSC80467Cas No. 101982-51-8
NSC 80467 is a selective DNA-damaging agent that functions through survivin inhibition. NSC 80467 preferentially disrupts DNA synthesis, thereby inducing two hallmark DNA-damage markers, γH2AX and pKAP1. NSC 80467 enables mechanistic investigation in to DNA replication stress and apoptosis-associated signaling pathways and serves as a biochemical tool for evaluating survivin-dependent cellular processes in oncology research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $58 | - | In Stock | |
| 5 mg | $139 | - | In Stock | |
| 10 mg | $228 | - | In Stock | |
| 25 mg | $459 | - | In Stock | |
| 50 mg | $677 | - | In Stock | |
| 100 mg | $963 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.25%
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Product Introduction
Bioactivity
Chemical Properties
| Description | NSC 80467 is a selective DNA-damaging agent that functions through survivin inhibition. NSC 80467 preferentially disrupts DNA synthesis, thereby inducing two hallmark DNA-damage markers, γH2AX and pKAP1. NSC 80467 enables mechanistic investigation in to DNA replication stress and apoptosis-associated signaling pathways and serves as a biochemical tool for evaluating survivin-dependent cellular processes in oncology research. |
| In vitro | NSC 80467 (200 or 800 nM, 24 hours) can inhibit the expression of survivin in PC3 cells [1]. |
| Synonyms | NSC80467 |
| Molecular Weight | 512.35 |
| Formula | C24H22BrN3O5 |
| Cas No. | 101982-51-8 |
| Smiles | O=C1C2=C(C(C3=C1N(CC(C)C)C(C)=[N+]3CC(C4=CC=C([N+]([O-])=O)C=C4)=O)=O)C=CC=C2.[Br-] |
| Color | Green |
| Appearance | Solid |
Storage & Solubility Information
| Storage | The compound is unstable in solution. Please use soon | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20.00 mg/mL (39.04 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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