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NSC 80467

Name: NSC 80467
Brand: TargetMol
SKU: T38414
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38414Cas No. 101982-51-8

Alias NSC80467

NSC 80467 is a selective DNA-damaging agent that functions through survivin inhibition. NSC 80467 preferentially disrupts DNA synthesis, thereby inducing two hallmark DNA-damage markers, γH2AX and pKAP1. NSC 80467 enables mechanistic investigation in to DNA replication stress and apoptosis-associated signaling pathways and serves as a biochemical tool for evaluating survivin-dependent cellular processes in oncology research.

NSC 80467

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Purity: 99.25%

Catalog No. T38414Alias NSC80467Cas No. 101982-51-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$58	-	In Stock
5 mg	$139	-	In Stock
10 mg	$228	-	In Stock
25 mg	$459	-	In Stock
50 mg	$677	-	In Stock
100 mg	$963	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.25%

Appearance:Solid

Color:Green

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	NSC 80467 is a selective DNA-damaging agent that functions through survivin inhibition. NSC 80467 preferentially disrupts DNA synthesis, thereby inducing two hallmark DNA-damage markers, γH2AX and pKAP1. NSC 80467 enables mechanistic investigation in to DNA replication stress and apoptosis-associated signaling pathways and serves as a biochemical tool for evaluating survivin-dependent cellular processes in oncology research.
In vitro	NSC 80467 (200 or 800 nM, 24 hours) can inhibit the expression of survivin in PC3 cells [1].
Synonyms	NSC80467

Chemical Properties

Molecular Weight	512.35
Formula	C₂₄H₂₂BrN₃O₅
Cas No.	101982-51-8
Smiles	O=C1C2=C(C(C3=C1N(CC(C)C)C(C)=[N+]3CC(C4=CC=C([N+]([O-])=O)C=C4)=O)=O)C=CC=C2.[Br-]

Storage & Solubility Information

Storage

The compound is unstable in solution. Please use soon | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20.00 mg/mL (39.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9518 mL	9.7590 mL	19.5179 mL	97.5895 mL
5 mM	0.3904 mL	1.9518 mL	3.9036 mL	19.5179 mL
10 mM	0.1952 mL	0.9759 mL	1.9518 mL	9.7590 mL
20 mM	0.0976 mL	0.4879 mL	0.9759 mL	4.8795 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc