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Pitavastatin calcium

Name: Pitavastatin calcium
Brand: TargetMol
SKU: T2534
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2534Cas No. 147526-32-7

Alias Pitavastatin hemicalcium, P-872441, NK-104 hemicalcium

Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.

Pitavastatin calcium

🥰Excellent

Purity: 99.49%

Catalog No. T2534Alias Pitavastatin hemicalcium, P-872441, NK-104 hemicalciumCas No. 147526-32-7

Pack Size	Price	Availability
5 mg	$34	In Stock
10 mg	$54	In Stock
25 mg	$76	In Stock
50 mg	$98	In Stock
100 mg	$171	In Stock
200 mg	$239	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock

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Purity:99.49%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.
Targets&IC50	HMG-CoA:5.8 nM
In vivo	Pitavastatin inhibits the progression of arterial atherosclerosis by blocking the synthesis of thromboxane and suppressing the migration or proliferation of vascular smooth muscle induced by angiotensin II, thereby stabilizing atherosclerotic plaques. It significantly reduces the levels of intracellular and synthesized cholesteryl esters. Moreover, pitavastatin enhances the extracellular expression of LDL receptors and increases the binding of LDL to LDL receptors. Compared to simvastatin and atorvastatin, pitavastatin is more effective in inducing the expression of LDL receptor mRNA.
Synonyms	Pitavastatin hemicalcium, P-872441, NK-104 hemicalcium

Chemical Properties

Molecular Weight	880.98
Formula	C₅₀H₄₆CaF₂N₂O₈
Cas No.	147526-32-7
Smiles	[Ca++].O[C@H](C[C@H](O)\C=C\c1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC([O-])=O.O[C@H](C[C@H](O)\C=C\c1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC([O-])=O
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (56.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1351 mL	5.6755 mL	11.3510 mL	56.7550 mL
5 mM	0.2270 mL	1.1351 mL	2.2702 mL	11.3510 mL
10 mM	0.1135 mL	0.5675 mL	1.1351 mL	5.6755 mL
20 mM	0.0568 mL	0.2838 mL	0.5675 mL	2.8377 mL
50 mM	0.0227 mL	0.1135 mL	0.2270 mL	1.1351 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc