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Pitavastatin calcium

Name: Pitavastatin calcium
Brand: TargetMol
SKU: T2534
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2534Cas No. 147526-32-7

Alias Pitavastatin hemicalcium, P-872441, NK-104 hemicalcium

Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.

Pitavastatin calcium

🥰Excellent

Purity: 99.49%

Catalog No. T2534Alias Pitavastatin hemicalcium, P-872441, NK-104 hemicalciumCas No. 147526-32-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$33	In Stock	In Stock
10 mg	$44	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$93	In Stock	In Stock
100 mg	$129	In Stock	In Stock
500 mg	$326	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.49%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.
Targets&IC50	HMG-CoA:5.8 nM
In vivo	Pitavastatin inhibits the progression of arterial atherosclerosis by blocking the synthesis of thromboxane and suppressing the migration or proliferation of vascular smooth muscle induced by angiotensin II, thereby stabilizing atherosclerotic plaques. It significantly reduces the levels of intracellular and synthesized cholesteryl esters. Moreover, pitavastatin enhances the extracellular expression of LDL receptors and increases the binding of LDL to LDL receptors. Compared to simvastatin and atorvastatin, pitavastatin is more effective in inducing the expression of LDL receptor mRNA.
Synonyms	Pitavastatin hemicalcium, P-872441, NK-104 hemicalcium

Chemical Properties

Molecular Weight	880.98
Formula	C₅₀H₄₆CaF₂N₂O₈
Cas No.	147526-32-7
Smiles	[Ca++].O[C@H](C[C@H](O)\C=C\c1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC([O-])=O.O[C@H](C[C@H](O)\C=C\c1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC([O-])=O
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (283.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1351 mL	5.6755 mL	11.3510 mL	56.7550 mL
5 mM	0.2270 mL	1.1351 mL	2.2702 mL	11.3510 mL
10 mM	0.1135 mL	0.5675 mL	1.1351 mL	5.6755 mL
20 mM	0.0568 mL	0.2838 mL	0.5675 mL	2.8377 mL
50 mM	0.0227 mL	0.1135 mL	0.2270 mL	1.1351 mL
100 mM	0.0114 mL	0.0568 mL	0.1135 mL	0.5675 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc