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Anti-Neuropilin-1 Antibody (3Z32)

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Catalog No. TMAY-00058
Alias VEGF165R, NRP, NP1, Neuropilin-1, neuropilin 1, CD304, BDCA4

Anti-Neuropilin-1 Antibody (3Z32) is a Mouse antibody targeting Neuropilin-1. Anti-Neuropilin-1 Antibody (3Z32) can be used in FCM.

Anti-Neuropilin-1 Antibody (3Z32)

Anti-Neuropilin-1 Antibody (3Z32)

😃Good
Catalog No. TMAY-00058Alias VEGF165R, NRP, NP1, Neuropilin-1, neuropilin 1, CD304, BDCA4
Anti-Neuropilin-1 Antibody (3Z32) is a Mouse antibody targeting Neuropilin-1. Anti-Neuropilin-1 Antibody (3Z32) can be used in FCM.
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100 μL$199 7-10 days
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Product Introduction

Bioactivity
Description
Anti-Neuropilin-1 Antibody (3Z32) is a Mouse antibody targeting Neuropilin-1. Anti-Neuropilin-1 Antibody (3Z32) can be used in FCM.
AliasVEGF165R, NRP, NP1, Neuropilin-1, neuropilin 1, CD304, BDCA4
Ig Type
Monoclonal Mouse IgG1
Clone
3Z32
Reactivity
Human
Verified Activity
Flow cytometric analysis of human NRP1(CD304) expression on HUVEC cells. Cells were stained with purified anti-Human NRP1, then a PE-conjugated second step antibody. The histogram were derived from events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
FCM: 1:25-1:100
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Neuropilin-1 / NRP1 / CD304 (rh Neuropilin-1 / NRP1 / CD304; TMPY-02367; NP_001019799.1; Met1-Lys644). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundNeuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a short cytoplasmic region. Neuropilin-1 (NRP1) acts as a receptor for two different extracellular ligands, class 3 semaphorins, and specific isoforms of vascular endothelial growth factor. The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they promote angiogenesis and cell migration. Neuropilin-1 is likely to mediate contacts between the dendritic cells and the T lymphocytes via homotypic interactions and is essential for the initiation of the primary immune response. NRP1 is a co-receptor for VEGF receptor-2 (VEGFR2) that enhances the binding of VEGF165 to VEGFR2 and VEGF165-mediated chemotaxis. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors. Overexpression of NRPI in rat tumor cells results in enlarged tumors and substantially enhanced tumor angiogenesis. On the other hand, soluble NRP1 (sNRP1) is an antagonist of tumor angiogenesis.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
APC/PE
Antibody Types Available
3
Antigen Details
Immunogen
Recombinant Human Neuropilin-1 / NRP1 / CD304 protein (TMPY-02367)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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