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PFB-FDGlu

Name: PFB-FDGlu
Brand: TargetMol
SKU: T39518
Price: 152 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39518Cas No. 209540-62-5

PFB-FDGlu is a lysosomal Glucocerebrosidase (GCase) substrate with cell-permeable specificity that is cleaved to produce fluorescein.PFB-FDGlu is often used in conjunction with a flow cytometer to measure GCase activity in living cells on an individual cell basis.

PFB-FDGlu

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Purity: 99.86%

Catalog No. T39518Cas No. 209540-62-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$152	In Stock	In Stock
5 mg	$373	In Stock	In Stock
10 mg	$556	In Stock	In Stock
25 mg	$896	In Stock	In Stock
50 mg	$1,220	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

ee:100%

Appearance:Solid

Color:Yellow

Resource Download

COA CSFC FNMR ORP LCMS HNMR

Product Introduction

Bioactivity

Description	PFB-FDGlu is a lysosomal Glucocerebrosidase (GCase) substrate with cell-permeable specificity that is cleaved to produce fluorescein.PFB-FDGlu is often used in conjunction with a flow cytometer to measure GCase activity in living cells on an individual cell basis.
In vitro	Cell-permeable PFB-FDGlu can be utilized with a flow cytometer to measure GCase activity in living cells on a single-cell basis[1].

Chemical Properties

Molecular Weight	865.66
Formula	C₃₉H₃₂F₅NO₁₆
Cas No.	209540-62-5
Smiles	O=C1OC2(C=3C1=CC(NC(=O)C4=C(F)C(F)=C(F)C(F)=C4F)=CC3)C=5C(OC=6C2=CC=C(O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)C6)=CC(O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)=CC5
Relative Density.	1.82 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (291.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1552 mL	5.7759 mL	11.5519 mL	57.7594 mL
5 mM	0.2310 mL	1.1552 mL	2.3104 mL	11.5519 mL
10 mM	0.1155 mL	0.5776 mL	1.1552 mL	5.7759 mL
20 mM	0.0578 mL	0.2888 mL	0.5776 mL	2.8880 mL
50 mM	0.0231 mL	0.1155 mL	0.2310 mL	1.1552 mL
100 mM	0.0116 mL	0.0578 mL	0.1155 mL	0.5776 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc