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FGH10019

Name: FGH10019
Brand: TargetMol
SKU: T7798
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7798Cas No. 1046045-61-7

Alias FGH-10019

FGH10019 is a novel inhibitor of sterol regulatory element-binding protein (SREBP) ( IC50 :1 μM).

FGH10019

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Purity: 98.93%

Catalog No. T7798Alias FGH-10019Cas No. 1046045-61-7

FGH10019 is a novel inhibitor of sterol regulatory element-binding protein (SREBP) ( IC50 :1 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$236	In Stock	In Stock
25 mg	$395	In Stock	In Stock
50 mg	$562	In Stock	In Stock
100 mg	$762	In Stock	In Stock
200 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$167	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.93%

Appearance:solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

FGH10019 AI Summary

FGH10019 exhibits numerous bioactivities, including significant inhibition of SREBP2 activation, which leads to the down-regulation of various genes involved in lipid metabolism such as stearoyl-CoA desaturase, MVK, HMG-CoA reductase, ATP citrate lyase, INSIG1, HMG-CoA synthase 1, isopentenyl diphosphate delta isomerase 1, and LDLR. The compound also exhibits antiobese activity in ob/ob C57BL/6J mice with positive effects on body weight, serum glucose, serum cholesterol, serum HDL and LDL levels, liver triglyceride levels, and a reduction in food intake. FGH10019 shows good aqueous solubility at both pH 3 and pH 7, favorable intrinsic clearance, acceptable half-life in mouse hepatocytes, and significant apparent permeability in PAMPA assays. In addition, FGH10019 displays potent antimicrobial activity against various clinical isolates of Mycobacterium tuberculosis, including some resistant strains, with low inhibitory concentrations (MIC < 0.5 µg/mL) observed after 7 days of exposure. It demonstrates good solubility (1300.0 nM), low unbound fraction in mouse plasma (Fu < 0.01), and moderate intrinsic clearance in both mouse liver microsomes (CL = 28.84 mL.min-1.g-1) and human liver microsomes (CL = 4.3 mL.min-1.g-1). Furthermore, in a luciferase reporter assay conducted in CHO-K1 cells, FGH10019 inhibits SREBP with an IC50 value of 700.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	FGH10019 is a novel inhibitor of sterol regulatory element-binding protein (SREBP) ( IC50 :1 μM).
Targets&IC50	SREBP:1 μM
Synonyms	FGH-10019

Chemical Properties

Molecular Weight	373.49
Formula	C₁₈H₁₉N₃O₂S₂
Cas No.	1046045-61-7
Smiles	CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NS(C)(=O)=O)cc1
Relative Density.	1.307 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 38 mg/mL (101.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6774 mL	13.3872 mL	26.7745 mL	133.8724 mL
5 mM	0.5355 mL	2.6774 mL	5.3549 mL	26.7745 mL
10 mM	0.2677 mL	1.3387 mL	2.6774 mL	13.3872 mL
20 mM	0.1339 mL	0.6694 mL	1.3387 mL	6.6936 mL
50 mM	0.0535 mL	0.2677 mL	0.5355 mL	2.6774 mL
100 mM	0.0268 mL	0.1339 mL	0.2677 mL	1.3387 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc