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JAK2-IN-14
Catalog No. T212993 Copy Product Info
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JAK2-IN-14 is an orally effective JAK2 inhibitor with an IC50 of 2 nM. It exhibits selectivity for JAK2 over JAK1, JAK3, and TYK2 by factors of 89.5, 80.5, and 51 times, respectively. JAK2-IN-14 inhibits the STAT5 signaling pathway and can cause tumor cell cycle arrest and apoptosis (apoptosis). It is applicable in the research of myeloproliferative neoplasms (MPN).
JAK2-IN-14
Copy Product Info🥰Excellent
Catalog No. T212993
JAK2-IN-14 is an orally effective JAK2 inhibitor with an IC50 of 2 nM. It exhibits selectivity for JAK2 over JAK1, JAK3, and TYK2 by factors of 89.5, 80.5, and 51 times, respectively. JAK2-IN-14 inhibits the STAT5 signaling pathway and can cause tumor cell cycle arrest and apoptosis (apoptosis). It is applicable in the research of myeloproliferative neoplasms (MPN).
JAK2-IN-14
Cas No. 3087335-24-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Chemical Properties
Storage & Solubility Information
| Description | JAK2-IN-14 is an orally effective JAK2 inhibitor with an IC50 of 2 nM. It exhibits selectivity for JAK2 over JAK1, JAK3, and TYK2 by factors of 89.5, 80.5, and 51 times, respectively. JAK2-IN-14 inhibits the STAT5 signaling pathway and can cause tumor cell cycle arrest and apoptosis (apoptosis). It is applicable in the research of myeloproliferative neoplasms (MPN). |
| Targets&IC50 | JAK2:2 nM |
| In vitro | JAK2-IN-14 (Compound 15au) induces significant G2/M phase cell cycle arrest and apoptosis in a dose-dependent manner within BaF3-JAK2 V617F and HEL cells at concentrations of 0.01-5 μM over 24 hours. Additionally, at concentrations of 0.05-1 μM over 2 hours, JAK2-IN-14 effectively inhibits the phosphorylation of JAK2 and its downstream signaling molecule STAT5 in these cells. |
| In vivo | JAK2-IN-14 (Compound 15au), administered orally at doses of 7.5-40 mg/kg once daily for 13-28 days, significantly inhibits tumor growth in xenograft mouse models of BaF3-JAK2 V617F and HEL cells. |
| Molecular Weight | 459.6 |
| Formula | C26H33N7O |
| Cas No. | 3087335-24-5 |
| Smiles | N1=CC(=C2NC1=NC=3C=CC(=C(OCCCCN4N=CC2=C4)C3)N5CCN(CC5)CC6CC6)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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