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eIF4A3-IN-1

Name: eIF4A3-IN-1
Brand: TargetMol
SKU: T11170
Price: 142 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11170Cas No. 2095486-67-0

eIF4A3-IN-1 is a selective and potent inhibitor of eukaryotic initiation factor 4A3 (eIF4A3) with an IC50 value of 0.26 μM. eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.

eIF4A3-IN-1

🥰Excellent

Purity: 99.89%

Catalog No. T11170Cas No. 2095486-67-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$142	In Stock	In Stock
2 mg	$208	-	In Stock
5 mg	$355	In Stock	In Stock
10 mg	$587	-	In Stock
25 mg	$1,170	-	In Stock
50 mg	$1,570	-	In Stock
100 mg	$2,120	-	In Stock
200 mg	$2,860	-	In Stock
1 mL x 10 mM (in DMSO)	$458	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	eIF4A3-IN-1 is a selective and potent inhibitor of eukaryotic initiation factor 4A3 (eIF4A3) with an IC50 value of 0.26 μM. eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.
Targets&IC50	eIF4A3:0.2 μM, eIF4A3:0.043 μM (Kd)

Chemical Properties

Molecular Weight	588.88
Formula	C₂₉H₂₃BrClN₅O₂
Cas No.	2095486-67-0
Smiles	C(=O)(N1[C@H](CN(C(=O)C2=C(C)N(N=C2)C3=CC(C#N)=CC=C3)CC1)C4=CC=C(Cl)C=C4)C5=CC=C(Br)C=C5
Relative Density.	1.45 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (271.70 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6981 mL	8.4907 mL	16.9814 mL	84.9069 mL
5 mM	0.3396 mL	1.6981 mL	3.3963 mL	16.9814 mL
10 mM	0.1698 mL	0.8491 mL	1.6981 mL	8.4907 mL
20 mM	0.0849 mL	0.4245 mL	0.8491 mL	4.2453 mL
50 mM	0.0340 mL	0.1698 mL	0.3396 mL	1.6981 mL
100 mM	0.0170 mL	0.0849 mL	0.1698 mL	0.8491 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc