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Leminoprazole

Name: Leminoprazole
Brand: TargetMol
SKU: T27812
Price: 78 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27812Cas No. 104340-86-5

Leminoprazole is an orally available H+,K(+)-ATPase inhibitor that protects gastric mucosal cells from various cellular damages.

Leminoprazole

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Purity: 99.79%

Catalog No. T27812Cas No. 104340-86-5

Leminoprazole is an orally available H+,K(+)-ATPase inhibitor that protects gastric mucosal cells from various cellular damages.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$78	In Stock	In Stock
5 mg	$192	In Stock	In Stock
10 mg	$288	In Stock	In Stock
25 mg	$472	In Stock	In Stock
50 mg	$648	In Stock	In Stock
100 mg	$888	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.79%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Leminoprazole is an orally available H+,K(+)-ATPase inhibitor that protects gastric mucosal cells from various cellular damages.
Targets&IC50	K+-ATPase:31 μM
In vitro	Leminoprazole, when given orally at doses of 10-100 mg/kg, was able to dose-dependently inhibit H+, K(+)-ATPase activity at 3 and 6 hours after administration. Specifically, Leminoprazole (60 mg/kg, p.o.) inhibited H+, K(+)-ATPase for a much longer duration than omeprazole (30 mg/kg, p.o.). In pylorus ligated rats, the inhibitory effect of Leminoprazole on gastric acid secretion and its inhibitory rate on H+, K(+)-ATPase activity showed a good correlation, suggesting that the inhibitory efficacy of Leminoprazole in inhibiting gastric acid secretion via H+, K(+)-ATPase activity is comparable to that of omeprazole. The inhibitory effect was comparable to that of omeprazole. In addition, Leminoprazole (100 mg/kg) directly inhibited H+, K(+)-ATPase activity even when administered intragastrically after pyloric ligation, demonstrating the ability of this compound to inhibit H+, K(+)-ATPase activity directly from the gastric lumen. Further studies showed that continuous administration of Leminoprazole (100 mg/kg, p.o.) for 2 or 4 weeks had the same inhibitory effect on H+, K(+)-ATPase as a single dose.
In vivo	Leminoprazole, when given orally at doses of 10-100 mg/kg, was able to dose-dependently inhibit H+, K(+)-ATPase activity at 3 and 6 hours after administration. Specifically, Leminoprazole (60 mg/kg, p.o.) inhibited H+, K(+)-ATPase for a much longer duration than omeprazole (30 mg/kg, p.o.). In pylorus ligated rats, the inhibitory effect of Leminoprazole on gastric acid secretion and its inhibitory rate on H+, K(+)-ATPase activity showed a good correlation, suggesting that the inhibitory efficacy of Leminoprazole in inhibiting gastric acid secretion via H+, K(+)-ATPase activity is comparable to that of omeprazole. The inhibitory effect was comparable to that of omeprazole. In addition, Leminoprazole (100 mg/kg) directly inhibited H+, K(+)-ATPase activity even when administered intragastrically after pyloric ligation, demonstrating the ability of this compound to inhibit H+, K(+)-ATPase activity directly from the gastric lumen. Further studies showed that continuous administration of Leminoprazole (100 mg/kg, p.o.) for 2 or 4 weeks had the same inhibitory effect on H+, K(+)-ATPase as a single dose.

Chemical Properties

Molecular Weight	341.47
Formula	C₁₉H₂₃N₃OS
Cas No.	104340-86-5
Smiles	S(CC1=C(N(CC(C)C)C)C=CC=C1)(=O)C=2NC=3C(N2)=CC=CC3
Relative Density.	1.25g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (146.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9285 mL	14.6426 mL	29.2851 mL	146.4257 mL
5 mM	0.5857 mL	2.9285 mL	5.8570 mL	29.2851 mL
10 mM	0.2929 mL	1.4643 mL	2.9285 mL	14.6426 mL
20 mM	0.1464 mL	0.7321 mL	1.4643 mL	7.3213 mL
50 mM	0.0586 mL	0.2929 mL	0.5857 mL	2.9285 mL
100 mM	0.0293 mL	0.1464 mL	0.2929 mL	1.4643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc