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Anti-Phospho-Chk2 (Thr68) Antibody (7T986)
😃Good
Catalog No. TMAY-01664
Alias TPDS4, RAD53, PP1425, Phospho-Chk2 (T68), p-Chk2 (Thr68), p-Chk2 (T68), LFS2, HuCds1, hCds1, Chk2 (p-Thr68), Chk2 (p-T68), CHK-2, CDS1, bA444G7
Anti-Phospho-Chk2 (Thr68) Antibody (7T986) is a Rabbit antibody targeting Phospho-Chk2 (Thr68). Anti-Phospho-Chk2 (Thr68) Antibody (7T986) can be used in WB.
Anti-Phospho-Chk2 (Thr68) Antibody (7T986)
Anti-Phospho-Chk2 (Thr68) Antibody (7T986)
😃Good
Catalog No. TMAY-01664Alias TPDS4, RAD53, PP1425, Phospho-Chk2 (T68), p-Chk2 (Thr68), p-Chk2 (T68), LFS2, HuCds1, hCds1, Chk2 (p-Thr68), Chk2 (p-T68), CHK-2, CDS1, bA444G7
Anti-Phospho-Chk2 (Thr68) Antibody (7T986) is a Rabbit antibody targeting Phospho-Chk2 (Thr68). Anti-Phospho-Chk2 (Thr68) Antibody (7T986) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $80 | 7-10 days | |
| 100 μL | $235 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: WB Reactivity: Human |
| Alias | TPDS4, RAD53, PP1425, Phospho-Chk2 (T68), p-Chk2 (Thr68), p-Chk2 (T68), LFS2, HuCds1, hCds1, Chk2 (p-Thr68), Chk2 (p-T68), CHK-2, CDS1, bA444G7 |
| Ig Type | Rabbit IgG |
| Clone | 7T986 |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of extracts from HCT116, untreated (-) or treated with Etoposide (100 μM, 2 h) (+), using Phospho-Chk2 (Thr68) Antibody, Rabbit MAb at 1:500 dilution (upper) or Anti-CHEK2 Antibody, Rabbit PAb (middle) at 1:1000 dilution or Beta-Tubulin Loading Control Antibody, Mouse Mab at 1:10000 dilution. 2. Western blot analysis of extracts from HCT116, untreated (line A); treated with Etoposide (100 μM, 2 h), without peptide (line B) or antigen-specific phosphopeptide (line C) or antigen-specific peptide (line D) using Phospho-Chk2 (Thr68) Antibody, Rabbit MAb at 1:500 dilution. (Validation Experiment) 3. Western blot analysis of extracts from HCT116, untreated (line A); treated with Etoposide (100 μM, 2 h) (line B); treated with Etoposide and λ-phosphatase (line C) using Phospho-Chk2 (Thr68) Antibody, Rabbit MAb at 1:500 dilution. (Validation Experiment) 4. Western blot analysis of extracts from HCT116, treated with Etoposide (100μM, 2 h), using Phospho-Chk2 (Thr68) Antibody, Rabbit MAb and other brands’ antibodies (Company C) at dilution of 1:1000, 1:5000. (Validation Experiment) |
| Application | WB |
| Recommended Dose | WB: 1:1000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around Thr68 of the Human Chk2. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| Research Background | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by CHEK2 gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded CHEK2 protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in CHEK2s gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: residues around Thr68 of the Human Chk2 |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, Tumor Suppressors |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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