Shopping Cart
Remove All
Your shopping cart is currently empty
PKCβ inhibitor 1
Copy Product Info
🥰Excellent
Catalog No. T8376Cas No. 257879-35-9
Alias KUN79359
PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively).
PKCβ inhibitor 1
Copy Product Info🥰Excellent
Purity: 99.33%
Catalog No. T8376Alias KUN79359Cas No. 257879-35-9
PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 μg | $33 | In Stock | In Stock | |
| 1 mg | $46 | In Stock | In Stock | |
| 5 mg | $108 | In Stock | In Stock | |
| 10 mg | $196 | In Stock | In Stock | |
| 25 mg | $435 | In Stock | In Stock | |
| 50 mg | $768 | In Stock | In Stock | |
| 100 mg | $1,050 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $118 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.33%
Appearance:Solid
Color:Yellow
Contact us for more batch information
Product Introduction
PKCβ inhibitor 1 AI Summary
PKCβ inhibitor 1 exhibits potent inhibitory activity against multiple protein kinase C (PKC) isoforms, particularly PKC beta 2 with an IC50 value of 5.0 nM, indicating high potency against this isoform. It also inhibits PKC beta 1, PKC alpha, and PKC epsilon, though to a lesser extent. Additionally, PKCβ inhibitor 1 shows selectivity in inhibiting JAK3 over JAK2, with an IC50 value of 17.0 nM for JAK3 and a selectivity ratio of 226.0. It also inhibits TYK2, JAK2, and JAK1 with respective IC50 values of 2310.0 nM, 3850.0 nM, and 770.0 nM. Furthermore, the compound demonstrates varying degrees of thermal melting changes on several protein targets involved in cellular signaling pathways, such as AMPKA2, CAMKs, CDKs, GSK3B, JAK1~B, PLKs, RSKs, SLK, and RIOK2, suggesting potential bioactivity in modulating the stability and function of these proteins..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively). |
| Targets&IC50 | PKCα:331 nM, PKCβ1 (human):21 nM , PKCβ2 (human):5 nM |
| Synonyms | KUN79359 |
| Molecular Weight | 411.46 |
| Formula | C24H21N5O2 |
| Cas No. | 257879-35-9 |
| Smiles | O=C1NC(=O)C(=C1Nc1ccccc1)c1cn(CCCn2ccnc2)c2ccccc12 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.12 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.43 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy PKCβ inhibitor 1 | purchase PKCβ inhibitor 1 | PKCβ inhibitor 1 cost | order PKCβ inhibitor 1 | PKCβ inhibitor 1 chemical structure | PKCβ inhibitor 1 formula | PKCβ inhibitor 1 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.