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3-Deoxysappanchalcone

Name: 3-Deoxysappanchalcone
Brand: TargetMol
SKU: TN1245
Price: 136 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1245 Copy Product Info

Purity: 99.65%

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3-Deoxysappanchalcone is a natural chalcone compound with various biological activities, including anti-allergic, antiviral, and antioxidant properties. 3-Deoxysappanchalcone directly targets MET, EGFR, AKT, mTOR, p38 MAPK, JNK, and the neuraminidase of the influenza virus, thereby regulating related signaling pathways. 3-Deoxysappanchalcone also exhibits antithrombotic potential, effectively inhibiting platelet aggregation by prolonging activated partial thromboplastin time (aPTT) and prothrombin time (PT), and by inhibiting the activity of thrombin (FIIa) and activated factor X (FXa).

Cas No. 112408-67-0

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Pack Size	Price	USA Stock	Global Stock
1 mg	$136	-	In Stock
5 mg	$289	-	In Stock
10 mg	$433	-	In Stock
25 mg	$782	-	In Stock
50 mg	$1,060	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.65%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	3-Deoxysappanchalcone is a natural chalcone compound with various biological activities, including anti-allergic, antiviral, and antioxidant properties. 3-Deoxysappanchalcone directly targets MET, EGFR, AKT, mTOR, p38 MAPK, JNK, and the neuraminidase of the influenza virus, thereby regulating related signaling pathways. 3-Deoxysappanchalcone also exhibits antithrombotic potential, effectively inhibiting platelet aggregation by prolonging activated partial thromboplastin time (aPTT) and prothrombin time (PT), and by inhibiting the activity of thrombin (FIIa) and activated factor X (FXa).
Targets & IC50	Ca9-22 cells:57.56 μM, RAW 264.7 cells:8.1 μM, HT1080 cells:26.7 μM, HeLa cells:33.3 μM, 3T3-L1 cells:41.8 μM, HepG2 cells:7.37 μM, H3N2:1.06 μM, Hep 3B2 cells:17.89 μM, B16-BL6 cells:49.9 μM, MDA-MB-231 cells:44.44 μM, A549 cells:32.6 μM, MCF7:51.41 μM
In vitro	3-Deoxysappanchalcone (6–12 μM; 48 h) inhibits the phosphorylation of EGFR, MET, AKT, and ERK in HCC827GR, a gefitinib-resistant human lung adenocarcinoma cell line; After 48 hours of treatment with 12 μM, p-EGFR was reduced to 0.31 times that of the control group, and p-MET was reduced to 0.24 times that of the control group [1]. 3-Deoxysappanchalcone (6–12 μM; 48 h) induces apoptotic cell death in gefitinib-resistant human lung adenocarcinoma cells HCC827GR in a dose-dependent manner [1]. At concentrations of 5 μM and above, 3-deoxysappanchalcone (1–20 μM; 1 min) significantly prolongs aPTT and PT in human plasma, with concentrations of 18.7 μM and 17.3 μM required to double aPTT and PT, respectively [4]. 3-Deoxysappanchalcone inhibits the neuraminidase (NA) of influenza A virus A/PR/8/34 (H1N1) with an IC50 of 14.6 μg/mL [5]. 3-Deoxysappanchalcone inhibits the neuraminidase (NA) of influenza A virus A/Guangdong/243/72 (H3N2) with an IC50 of 17.4 μg/mL [5]. 3-Deoxysappanchalcone inhibits the neuraminidase (NA) of influenza virus B/Jiangsu/10/2003, with an IC50 of 18.6 μg/mL [5].
In vivo	3-Deoxysappanchalcone (3-DSC) (50 mg/kg; intraperitoneal injection; single dose administered 1 hour prior to LPS challenge) provided 100% survival protection against LPS-induced lethal systemic inflammation in male C57BL/6 mice [2]. 3-Deoxysappanchalcone (intravenous injection, 0.02–0.4 mg/kg) significantly prolonged the bleeding time following tail amputation in male C57BL/6 mice at doses of 0.1 mg/kg, 0.2 mg/kg, and 0.4 mg/kg, with the highest tested dose (0.4 mg/kg) extending bleeding time to 82.3 s [4]. 3-Deoxysappanchalcone (intravenous injection, doses of 0.02–0.4 mg/kg) significantly prolonged the ex vivo activated partial thromboplastin time (aPTT) and prothrombin time (PT) in male C57BL/6 mice, with the highest tested dose (0.4 mg/kg) increasing aPTT to 47.9 s and PT to 29.4 s[4].

Chemical Properties

Molecular Weight	270.28
Formula	C₁₆H₁₄O₄
Cas No.	112408-67-0
Smiles	C(/C=C/C1=CC=C(O)C=C1)(=O)C2=C(OC)C=C(O)C=C2
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (147.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6999 mL	18.4993 mL	36.9987 mL	184.9933 mL
5 mM	0.7400 mL	3.6999 mL	7.3997 mL	36.9987 mL
10 mM	0.3700 mL	1.8499 mL	3.6999 mL	18.4993 mL
20 mM	0.1850 mL	0.9250 mL	1.8499 mL	9.2497 mL
50 mM	0.0740 mL	0.3700 mL	0.7400 mL	3.6999 mL
100 mM	0.0370 mL	0.1850 mL	0.3700 mL	1.8499 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NO SynthasemTORAkt3-Deoxysappanchalcone3Deoxysappanchalcone3 Deoxysappanchalcone

Related Tags: 3-Deoxysappanchalcone chemical structure | 3-Deoxysappanchalcone in vivo | 3-Deoxysappanchalcone in vitro | 3-Deoxysappanchalcone formula | 3-Deoxysappanchalcone molecular weight