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Arprinocide

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Catalog No. T9517Cas No. 55779-18-5

Arprinocide is a hypoxanthine-guanine transport inhibitor.

Arprinocide

Arprinocide

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🥰Excellent
Purity: 98.07%
Catalog No. T9517Cas No. 55779-18-5
Arprinocide is a hypoxanthine-guanine transport inhibitor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
500 mg$29In StockIn Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.07%
Appearance:Solid
Color:White
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Product Introduction

Arprinocide AI Summary
Arprinocide has demonstrated significant anticoccidial activity in chickens, with an 80.0% reduction in Eimeria acervulina and Eimeria tenella. It also exhibits bioactivity in blocking the entry of the Ebola virus, with AC50 values of 44.67 µM and 44668.4 nM in two screening tests. Additionally, Arprinocide shows antiparasitic activity against Toxoplasma gondii tachyzoites with an IC50 of 7000.0 nM. In infected mice, a dose of 10 mg/kg resulted in a 100.0% survival rate relative to the control group..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
Arprinocide is a hypoxanthine-guanine transport inhibitor.
Chemical Properties
Molecular Weight277.68
FormulaC12H9ClFN5
Cas No.55779-18-5
SmilesNc1ncnc2n(Cc3c(F)cccc3Cl)cnc12
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 4.8 mg/mL (17.29 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6013 mL18.0063 mL36.0127 mL180.0634 mL
5 mM0.7203 mL3.6013 mL7.2025 mL36.0127 mL
10 mM0.3601 mL1.8006 mL3.6013 mL18.0063 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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